Effects Of Chronic Aspirin Ingestion On Learning And Memory

Aspirin is also known as acetylsalicylic acid, which is a classic non-steroidal anti-inflammatory drugs, it has been used for clinical from 1899. Its main role is anti-pyretic, analgesic, anti-rheumatoid and antithrombotic. At present, low-dose aspirin is widely used in primary and secondary disease prevention of ischemic cerebrovascular disease.the effect of chronic low-dose aspirin ingestion on learning and memory for normal adult and patients with vascular dementia has not been reported at home and abroad. In this study, we investigate the effect of chronic low-dose aspirin ingestion on learning and memory for adult mice, chronic low-dose aspirin and chronic combi-nation (aspirin, octahydroaminoacridine succinate) ingestion on learning and memory for vascular dementia rats from behavioral tests, pathology, cholinergic system and free radical. The results show:1. effects of chronic aspirin ingestion on learning and memory for adult miceAspirin group was treated with aspirin (7.09～12.41 mg/kg) for three months, compared with control group:â‘ Latency and distance decreased from the 2st day to the 4th day. Starting angle, average speed did not significantly change from the 1st day to the 4th day. In two minutes times of passing platform, time in platform, time in platform quadrant, the percentage of distance in platform/total distance, starting angle and average speed also did not significantly change on the 5th day. The strategy of searching platform did not significantly change in Morris water maze test.â‘¡Error times and latency did not significantly change on the 2nd day in step through test.â‘¢Error times did not significantly change on the 1st and 2nd day, latency did not prolong on the 2nd day in step-down test.â‘£The content of ACh and the activity of AChE increased.⑤The activity of SOD increased, the content of MDA, the activity of SOD, GSH-Px, Na+-K+-ATPase and Ca²⁺-Mg²⁺-ATPase did not change. We came to the conclusion that aspirin can improve learning and memory of adult mice. It is may be related to cholinergic system improving and the enhancing of free radical scavenging.2. effects of chronic aspirin ingestion on learning and memory for bilateral ca-rotid artery ligation model ratsAspirin group was treated with aspirin (4.50～9.10 mg/kg) for two months, compared with control group:â‘ Latency and distance increased on the 5th day. Start-ing angle, average speed did not significantly change from the 1st day to the 6th day. In two minutes times of passing platform, time in platform, time in platform quadrant, the percentage of distance in platform/total distance, starting angle and average speed also did not significantly change on the 7th day. The strategy of searching platform did not significantly change in Morris water maze test.â‘¡Error times and latency did not significantly change on the 2nd day in step through test.â‘¢The content of ACh did not significantly change and the activity of AChE increased.â‘£The activity of SOD, Na+-K+-ATPase and Ca²⁺-Mg²⁺-ATPase increased, the content of MDA, the activity of GSH-Px, did not change. We came to the conclusion that aspirin has no effect on learning and memory of bilateral carotid artery ligation model rats from behavioral tests, but it can reduc the free radical damage.3. effects of chronic aspirin ingestion on learning and memory for the four-vessel occlusion ischemia-reperfusion model ratsAspirin group was treated with aspirin (9mg/kg) for two months,compared with control group:â‘ Latency decreased from the 3th day to the 4th day. Distance de-creased from the 3th day to the 5th day. Starting angle, average speed did not signifi-cantly change from the 1st day to the 6th day. In two minutes times of passing plat-form, time in platform, time in platform quadrant, the percentage of distance in plat-form/total distance, starting angle and average speed also did not significantly change on the 7th day. It speeded up that the searching strategy turned to linear type and trend type on the 5th day in Morris water maze test.â‘¡Error times and latency did not sig-nificantly change on the 2nd day in step through test.â‘¢The content of ACh and the activity of AChE did not significantly change.â‘£The activity of SOD and Na+-K+-ATPase increased, the content of MDA, the activity of GSH-Px and Ca²⁺-Mg²⁺-ATPase did not change. We came to the conclusion that aspirin can im-prove learning and memory of the four-vessel occlusion model rats. Its mechanisms are possibly connected with the reduction of free radical damagement.Combination group was treated with aspirin (9 mg/kg) and octahydroaminoacridine succinate (1.4 mg/kg) for two months, compared with control group:â‘ Latency de-creased on the 2th day. Distance decreased on the 2th day. Starting angle, average speed did not significantly change from the 1st day to the 6th day. In two minutes times of passing platform, time in platform, time in platform quadrant, the percentage of distance in platform/total distance increased, starting angle and average speed did not significantly change on the 7th day. The strategy of searching platform did not significantly change in Morris water maze test.â‘¡Error times and latency did not significantly change on the 2nd day in step through test.â‘¢The content of ACh did not significantly change and the activity of AChE increased.â‘£The content of MDA, the activity of SOD, GSH-Px, Na+-K+-ATPase and Ca²⁺-Mg²⁺-ATPase did not change. We came to the conclusion that the combination of aspirin and ChEI can improve learning and memory of the four-vessel occlusion model rats.