Study Of Preventive And Therapeutic Effects Of Exercise Volume On Vascular Dementia

In this paper, we investigate the effect of exercise volume on learning and memory in senile dementia mice and determine the mechanism preliminarily. At first,to introduce vascular dementia clinical research and basic research at home and abroad, and to analyze the relationship between exercise and vascular dementia, in order to show that the research significance. Experimental effects of exercise volume on learning and memory, free radical of brain, morphology in hippocampus slices, microcirculation of mice and the impact of hypoxia tolerance. MethodsThe mice were ip. sodium nitrite to prepare memory consolidated disability model. After 6 weeks of exercise with the running wheels, water maze task was used to evaluate the learning and memory function of mice, Colorimetric detection of brain superoxide dismutase (SOD) activity and malondialdehyde (MDA) content, HE morphological changes in hippocampus were observed; BI-2000 image analysis system was used to evaluate the microcirculation; The hypoxia tolerance were observed on acute anoxia mice. ResultsThe results showed that as compared with control group, the escape latency in directional swimming was significantly prolonged(P<0.05), SOD activity was decreased and the content of MDA was significantly increased(P<0.05), the hippocampus neuronal degeneration, falls off in hippocampus slices in mice, hypoxia significantly prolonged survival time; Compared with the model group, significantly improved the target role. Compared with the control group, exercise significantly improved microcirculation, increase hypoxia tolerance. ConclusionExercise has improving effect on learning and memory in mice deficits. The mechanism may be related to decreasing the free radical, improving the microcirculation and enhancing the effect of anti-anoxia in mice.