| Objective To assess the feasibility and efficacy of the noninvasive ventilation (NIV) to home in COPD with hyper-capnic respiratory failure (HRF) during the stable phase.Methods From January of 2002 to May of 2005, 31 inpatients with COPD and severe HRF who conducted by NIV via facialmask were enrolled. After discharged from hospita,l NIV to home was used in 15 cases (the study group). Meanwhile another 16 cases with similar clinical characteristics received oxygen inspiration (the control group).Results Patients in the study group and the control group had similar gas exchange profiled before and after ventilation with similarduration ofNIV during their hospital stay. Six months later and one year \two years later after discharge, the arterial partial pressure of carbon dioxide (PaCO2) was reduced in the study group than in the control group (P<0.05). Meanwhile the PaO2 was increased in the study group. The forced expiratory volume in 1 second (FEV1) was increased in the study group than the control groups (P<0.05). The average number of re-hospital-ization per year was 2 and 10 times (P<0.05), and themortality was 13.13% and 62.5% (P<0.05), respectively for the study and control groups.Conclusion For COPD patients who received NIV in hospita,l the intermittentNIV at home during the stable phasemay not only significantly decrease PaCO2 and reduce the frequencies of re-hospitalization but also improve the pulmonary function and the quality of life.1. gas exchange profiledcontinuous noninvasive ventilation (NIV) can improve gas exchange profiled,2. condition of lifeThe condition of life have been improved in study group, the QOL and MMRC ,6MWD have had significantly increased than the control group.3. the frequencies of re-hospitalization and invasive ventilation, the rate of death the frequencies of re-hospitalization and invasive ventilation, the rate of death have been reduced in study group than the control group.
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