Clinical Study Of Respiratory Failure Of Chronic Obstructive Pulmonary Disease Treated By Combining Chengqi Enteroclyster And Noninvasive Ventilation

Objective: COPD, respiratory system disease, cause respiratory failure that lead to death. Noninvasive positive pressure ventilation has gradually become the way that treats respiratory failure of COPD. But its application restricted by adverse reactions such as gastric bowel to bilge gas, aspiration. Prophase research confirmed that Chengqi enteroclyster adjuvant treat to respiratory failure by cleaning phlegm relieving and qi and blood. It not only can effectively improve the respiratory function, but also maintain normal gastrointestinal function. The topic focuses on the effect of respiratory failure of chronic obstructive pulmonary disease treated by combing chengqi enteroclyster and noninvasive ventilation through randomized controlled trials. as well as through phlegm relieving and qi and blood method to reduce adverse reactions like the noninvasive positive pressure ventilation, to explore more perfect combination of Chinese and western medicine therapy for the treatment of respiratory failure of COPD. Method: Based on standard cases, selected 96 cases of COPD patients with respiratory failure from August 2012 to August 2014 in luzhou medical school affiliated hospital. According to the order was in the hospital were divided into treatment group and control group which each one is 48 cases, and it must follow to randomly. The control group used noninvasive ventilation in conventional western medicine treatment and the treatment group on the basis of the control takes Chinese medicine medicinal Chengqi enteroclyster and intestinal fluid retention enema treatment, 1 time a day, 7 days for a period of treatment. The treatment of patients with visual reaction can be appropriately adjusted the dosage and course of treatment. Observation breathing, ventilation and oxygenation indexes of two groups, compared two groups of noninvasive ventilation in patients with abdominal distention, vomiting, aspiration machine related to the incidence of complications such as pneumonia and record the highest PS, the two groups PEEP, mechanical ventilation time, endotracheal intubation cases, successful cases and death cases from machine. At the same time the data by statistics is analyzed by using of statistical software SPSS. Result: It is concluded that the basic condition of two groups was no significant difference before treatment.(1)The clinical curative suggested that treatment group(96%) was significantly higher than control group(77%),Treatment group before and after treatment of TCM symptom score improvement extent there are differences in comparison with the control group(P < 0.01).(2) compare blood gas analysis index: The treatment group before and after treatment the PaCO2 and the PaO2 improvement extent there are differences in compared with the control group(P < 0.01, P < 0.05).(3)compare ventiolation: the treatment group before and after treatment the highest PS and the highest PEEP improvement extent there are differences in compared with the control group(P<0.01, P<0.05),and the mechanical ventilation time also(P < 0.05).(4)compare complications:the Complications after treatment group decreased significantly compared with controls,and the difference was statistically significant(P<0.05).(5) Treatment group endotracheal intubation rate and death cases and withdraw machine the successful cases there are differences between compared with control group(P <0.05).(6)The AST, ALT, BUN, Cr of Treatment group after treatment compared with controls no difference(P > 0.5). Conclusion: Combining Chengqi enteroclyster and noninvasive ventilation have four merits to patient. Firstly, it contribute to improving respiratory failure of COPD and can effectively improve clinical symptoms before and after treatment in patients with COPD complicated with respiratory failure.secondly, it can effectively reduce the patients’ mechanical ventilation time and death cases and improve the success rate of ventilator. Thirdly, it can reduce patient’s occurrence of complications such as abdominal distension, vomiting, aspiration. Fourthly, it has high security to treat respiratory failure of COPD.Fively, Bearing gas filling and intestinal juice with noninvasive positive pressure ventilation therapy for COPD complicated by respiratory failure of liver and kidney function safety indexes such as little smaller.