Experimental Studies On The Rat Models Of Parkinson's Disease With Xi-Feng-Ding-Chan Capsule

It is accepted at present that Parkinson's disease(PD) is an Idiopathic encephalopathy to be slowly progressive and intractable, and has no satisfying methods to treat yet.This paper describes and discusses a method to cure the PD-model white rat by giving the TCM of Xi-feng-ding-chan capsule and its influence to rat behavior, relevant bio-chemical criterion and histomorphology.In this experiment, author prepares a PD-model white rat by injecting the 6-OHDA into the rat's caudate putamen(CPu), and succeeds in designing and giving the TCM of Xi-feng-ding-chan capsule to the rats. As a result, rat not only survival but also remarkable improvement(p＜0.01)in behavior after being given the TCM of Xi-feng-ding-chan capsule. At same time, MDA content decrease, the content of GSH and GSH-PX increase, so the TCM of Xi-feng-ding-chan capsule can improve anti-oxygenstress ability of PD-model white rat, and abate lethal damage to dopaminergic neurons bringing out by anti-oxygen stress.Histomorphology detection suggests that TH-positive cells increase after TCM treatment, and that demonstrate that TCM of Xi-feng-ding-chan capsule can increase the expression of TH-positive cells, and thereby inhibit the rat rotation behaviour.This experiment proves the TCM of Xi-feng-ding-chan capsule not only feasible but also valid; at one time, it make clear the function mechanism of this kind of TCM, and establishes a theoretical and experimental basis for curing PD by the TCM of Xi-feng-ding-chan capsule, and provides a new idea and method.