Studies On The Underlying Mechanism Of Liver-qi Sthenic Dispersedness-Analyses On The Differential Expression Of Several Important Hormone And Neurotransmitter Receptor Genes In The Brain Tissue Of Premenstrual Syndrome Liver-qi Sthenia Symptom Macaque Mo

Objective: Premenstrual syndrome (PMS) liver-qi sthenia symptom is the type disease of Liver-qi Sthenic Dispersedness, which is the key point to study and explore nerve center monoaminergic neurotransmitters and hormone receptor genes. With its close relateness to the Underlying Mechanism of Liver-qi Sthenic Dispersedness,to explore the genes and the approach how it acts,furthermore,detect"liver-qi sthenic symptom complex of Traditional Chinese Medicine related deep mechanism"and"liver-qi sthenic symptom complex of Traditional Chinese Medicine related monoaminergic neurotransmitters and hormone"scientific hypothsis in gene level. Methods:Utilize the used subtractive cDNA library,make Macroarray gene chip to search different expression of genes.Results:nerve center monoaminergic neurotransmitters 5HT1AR,5HT2AR mRNA increase and GABARA mRNA decrease in the margin systen of PMS macaque model. hormone ERα,ERβmRNA decrease and PGR mRNA increase in the margin system of PMS macaque model. Conclusion:sustain scientific hypothsis,six candidacy genes are greatly related to PMS liver-qi sthenic symptom nerve center mechanism.