Association Of HLA-B Alleles With Eales Disease

Objective To study the relationship between HLA-B allele and the Eales disease , and find the disease-relative allele .Method 25 Eales disease patients were selected as research group, and 25 healthy people from Blood-Devote Center were selected as control group. DNA was gained from their peripheral blood, and HLA-B allele was determined by newly PCR-SSO method. The result was studied statistically.Result Genetype was tested in the two group, and relative serotype was got at the same time. No disease-caused allele was found in genetype analyze , but genetype HLA-B* 15 allele was significantly high in control group(P=0.0072).No disease-caused allele was found in serotype analyze too, but serotype HLA-B62 allele was significant high in control group(P=0.0090) also.Conclusion No disease-caused allele was found in HLA-B allele in this research. But genetype HLA-B* 15 allele and serotype HLA-B62 may have great influence in anti-disease process, which may means the cause of Eales disease was the lack of some HLA-B alleles.