| Eales disease known as peripheral retinal vein inflammation,1882 Henry Eales first reported the disease, which is a retinal vascular inflammatory diseases, Exudative to vascular inflammation, vitreous hemorrhage repeatedly characterized, has eyes for more than the incidence in the early lesions often involving only one quadrant fundus peripheral vein, gradually spread to the posterior pole and the other quadrant,and ultimately formed proliferative vitreoretinopathy lesions and secondary traction retinal detachment and blindness or serious harm vision。In young men in the high prevalence rate, a high rate of blindness. Research shows that the main retinal vein inflammation around the onset of the Indian subcontinent, mainly in the age 20 to 40 years old, 97.6 % were male. India 135 - 200 per eye patients in the one case of retinal vein inflammation around the case. China's young men retinal vein inflammation around the prevalence rate of 1 / 125, shows that the Chinese young people's health is a higher level of prevalence. Eales disease but also groups of young men in the more common blinding one eye. At present the disease in China has attracted more and more attention.At present Eales disease etiology and pathogenesis no clear conclusion, the majority of scholars believe that Eales disease by a variety of problems, arising from a variety of systems involved in diseases of the eye. Chinese and foreign experts have been gradually are reports suggested that autoimmune mechanisms exist in Eales in the pathogenesis of disease. In diabetes, lupus erythematosus, rheumatoid arthritis and other autoimmune diseases helper T lymphocytes (Th) of the changes in their immune mechanism has been identified.Objective Eales is a disease of the immune mechanism of the existence of the helper T lymphocyte cell factor changes, we Eales in the sera of patients with T helper lymphocytes and clinical testing factor analysis, the incidence of Eales disease mechanisms and provide a theoretical basis.Methods Luminex with more advanced detection technology Eales were detected in patients with first-episode case group, and cure the patient group and control group in serum Th1-type cell subsets secretion of cytokines IFN-γ, TNF_αand Th2 cell subsets secretion of cytokines IL-4 level changes. The results of analysis software SPSS13.0 One-Way ANOVA and non-parametric statistics for statistical analysis, P≤0.05 for the statistical difference.Results Eales patients Th1-type cytokines TNF_αcases in the first group, cure the patient group and control group respectively, in the concentration (23.12±0.79) pg / ml (12.52±0.17) pg / ml and (12.18±0.29) pg / ml. Starters cases and cure the patient group, P <0.001, the first cases and healthy controls, P <0.001, cure the patient group and control group, P = 0.04 <0.05, the group were statistically significant.IFN-γin the first patient group, and cure the patient group and control group respectively, in the concentration (18.35±1.14) pg / ml (7.17±0.29) pg / ml and (6.65±0.40) pg / ml, respectively. Starters cases and cure the patient group, P <0.001, the first cases and healthy controls, P <0.001, cure the patient group and control group, P = 0.03 <0.05, the group were statistically significant.Th2-type cytokines IL-4 in the first patient group, cure the patient group and control group respectively, in the concentration (4.26±0.09) pg / ml (4.20±0.15) pg / ml and (4.18±0.11) pg / ml. Starters cases and cure the patient group, P = 0.04 <0.05, the first cases and healthy controls, P = 0.02 <0.05, both statistically significant. Cure the patient group and control group, P = 0.67> 0.05, with no statistical significance.Th1 and Th2 representative of the ratio of IFN-γ/ IL-4 in the first patient group, cure the patient group and control group respectively, the ratio of (4.31±0.27), (1.71±0.04) and (1.59±0.07). Starters cases cured the patient group compared with P <0.001, the first case group compared with the healthy control group, P <0.001, cure the patient group and control group, P = 0.04 <0.05; have statistical significance.Conclusion Eales patients subsets in vivo secretion of Th1 cytokine IFN-γ, TNF_αand Th2 subsets secretion of cytokines IL-4 had significant change, and the ratio of Th1/Th2 increased. Subsets that the secretion of Th1 cytokines dominant, and Eales disease vasculitis, neovascularization,vitreous hemorrhage and poste- rior detachment of vitreous from the clinical manifestations such as a certain degree of relevance. T helper cell subsets in loss of balance involved in the immune mechanism Eales, to explore the pathogenesis of the disease and condition monitoring and seeking new prevention and treatment methods to provide a theoretical basis. |
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