Use Of Noninvasive Positive Pressure Ventilation In The Treatment For Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective: To assess the efficacy and safety of noninvasive positive pressure ventilation ( NIPPV ) for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients on general wards.Methods: A trial was conducted in the second affiliated hospital,ZJU between 2005.11 and 2006.2. 40 AECOPD patients were recruited ongeneral wards and assigned to standard medical treatment (group A, n= 25) or early administration of NIPPV plus standard medical treatment(group B, n = 15) .Results: The characteristics of the two groups on admission were similar. Arterial partial pressure of oxygen (PaO₂) and arterial partial pressure of carbon dioxide (PaCO₂) improved significantly in group B. The mortality was no significant difference between the two groups.Conclusions: The early use of NIPPV on general wards improvesarterial blood gas and respiratory pattern0 NIPPV is indicative for alleviating respiratory muscle fatigue and preventing respiratory failure from exacerbation,,...