Significance Of Serotonin And 5-hydroxy-indole Aectic Acid In Plasma And Cerebrospinal Fluid In Patients With Primary Epilepsy

Objective: To explore the relationship among 5-HT/5-HIAA in plasma and CSF, primary epilepsy and epilepsy associated with depression.Methods: 80 in-patients were collected and divided into the groups of epilepsy and control. The patients with epilepsy were subdivided into epilepsy group and epilepsy with depression group according to CCMD-3. The patients with epilepsy and depression were divided into three degrees according to the results of their HAMD. The patients with epilepsy were divided into two groups of treatment and untreatment. The levels of 5-HT/5-HIAA in plasma and CSF were all detected with fluorescence spectrophotometry in those groups.Results: Concentrations of 5-HT/5-HIAA in plasma and CSF were significantly different among the groups of epileptic patients, epileptics associated with depression and the controls (p<0.01). Obvious different levels of 5-HT/5-HIAA in plasma and CSF were detected in different seizure frequencies or degrees of depression and were detected between groups of treatment and untreatment (p<0. 01).Conclusions: There was a significant decrease of 5-HT/5-HIAA of plasma and CSF in epileptic patients and the epileptic patients with depression, also a significant difference of that between these two groups. There is a positive relationship between the changes of 5-HT/5-HIAA levels and the seizure frequencies or depression degrees. AEDs can raise concentrations of 5-HT/5-HIAA in CSF.