Study On The Relationship Between Serum Insulin-like Growth Factor-1 And Depression In Patients With Epilepsy

Objective:The purpose of this study was to explore the correlation between serum insulin-like growth factor-1(IGF-1)and epilepsy comorbid depression,and to provide a possible basis for exploring new markers of epilepsy comorbid disease.Methods:47 patients with epilepsy who were hospitalized in The First Affiliated Hospital of Xi’an Medical University from October 2019 to December 2020 were included in the epilepsy group.In the same period,25 people who matched their sex,age and education level in the physical examination department of our hospital were included as the control group.The socio-demographic and clinical data of all subjects were collected.The level of depression was evaluated by Hamilton depression scale and Self-rating depression scale,and the level of serum IGF-1 was detected by enzyme-linked immunosorbent assay.T-test,χ~2 test,analysis of variance,rank sum test,nonparametric Spearman rank correlation test,and univariate linear regression analysis were used for statistical analysis.Results:1.The incidence of depressive disorders was higher in the epilepsy group(31.9%)than in the control group(8%).HAMD score in epilepsy group was higher than that in control group(Z=-2.426,P=0.015).The comparison of HAMD scores among different clinical feature groups of patients with epilepsy showed that there were significant differences in HAMD scores among different course of disease,seizure frequency,duration and medication groups(P<0.05).Spearman correlation analysis between different clinical features and HAMD score in epilepsy group showed that there was a positive correlation between course of disease(r_s=0.412,P=0.004),seizure frequency(r_s=0.457,P=0.001),duration(r_s=0.306,P=0.037),medication(r_s=0.361,P=0.013)and HAMD score.2.The comparison of serum IGF-1 level between epilepsy group and control group showed that the level of serum IGF-1 in epilepsy group was higher than that in control group(t=3.174,P=0.002).The results of comparison of serum IGF-1 levels in different clinical feature groups showed that there were significant differences in serum IGF-1 levels among different sex,course of disease,seizure type,seizure frequency and medication group(P<0.05).The results of correlation analysis between different clinical features and serum IGF-1 level in epilepsy group showed that serum IGF-1 level was positively correlated with course of disease(r_s=0.457,P=0.001),seizure frequency(r_s=0.413,P=0.013),medication(r_s=0.608,P=0.000),and seizure type(r_s=-0.360,P=0.001).3.The level of serum IGF-1 in patients with depression was significantly higher than that in patients without depression,and the difference was statistically significant(t=5.887,P=0.000).There was no significant difference in serum IGF-1 levels among the three groups of epileptic patients with different degrees of depression.The results of Spearman rank correlation analysis between serum IGF-1 level and HAMD score in epileptic group showed that there was a positive correlation between serum IGF-1 level and HAMD score in patients with epilepsy(r_s=0.674,P=0.000).Conclusions:1.Serum IGF-1 levels were elevated in both epilepsy patients without depression and epilepsy patients with depression,and more significantly in epilepsy patients with depression.2.Serum IGF-1 levels in epilepsy patients may be affected by sex,course of disease,seizure type,seizure frequency and the use of antiepileptic drugs.