Experimental Study On Fracture Healing

Objective:on the basis of the animal experiment, verification of Jiegu Pill on fracture healing, and to explore its mechanism, provide the basis for clinicalapplication.Methods:experimental:the adult New Zealand rabbits were randomly divided into48, Jiegu pill group and Department of Traumatology Jiegupian group;will be left femoral neck after truncation screw fixation model made byoperation, the start of the second day were given Jiegu pill and Department of Traumatology Jiegupian intragastric administration; in the first,2,3weeksanimal drawn at death, heart blood and femoral neck fracture and bonemineral, observation and analysis of the biochemical indexes in detectionand callus tissue. Clinical part:80cases of patients with femoral neck fractures, according to the randomized double blinded principle, were givenJiegu pill and Department of Traumatology Jiegu tablets, which underwentclosed reduction and cannulated screw fixation, and monitoring of serumphosphorus, calcium and blood rheology index, postoperative regular Xslice observation of bone clinical healing degree, half a year after operationof hip joint the Harris score, after Unblinding of the indices compared.Results:experiment:two groups of animal blood calcium and phosphorus contents of blood in the healing process of no difference between the groups remained stable throughout the healing time of fracture; bone pillgroup was significantly shorter in the Department of TraumatologyJiegupian group fractures; each time point callus bone mineral density Jiegupill group was significantly better than the Department of TraumatologyJiegupian group. Clinical part:the drug for third months, sixth months,twelfth months of X-ray fracture healing score analysis showed that bone pillgroup is better than the Department of Traumatology Jiegupian group;6months postoperative Harris hip function score, Jiegu pill group is90.22+6.89, Department of Traumatology Jiegupian group is87.63+5.19, there was significant difference between them. Calcium and phosphorus, bloodrheology of two groups had no difference.Conclusion:Bone fracture healing pills are significantly better than injury healing tablets both in clinical efficacy and in promoting callus growth. They can yet be regarded as an ideal medicine to promote bone fracture healing.