Clinical Observation Of The Treatment Of Modified Shoutai Pills For Headache During Menstruation With Liver-blood Deficiency Pattern

Headache during menstruation is a common illness on clinic. It occurs during menstruation or befor\after menstruation. The main sympotmn is headache which stop after menstruation. Headache is acciated with menstruation. This illness is simply recored in <Zhang si yi tong>, and is belong to premenstrual tension syndrome in western medicine. This illness is treated as Nervous headache in western medicine. It is also called Menstrual migraine. The occour rate of this illness Gradually increasing following the Continuous development of society, accelerating pace of life and increasing pressure of women.it recurs With the emergence of the menstrual cycle and Serious impact on the lives of healthy women. It is attentioned by doctors.Objective:To study clinical effectiveness of Modified shoutai pills for headache during menstruation with liver-blood deficiency pattern. The experiment established Experimental group and control group. Experiment group give modified shoutai pills and control group give Siwutang decoction. The patients of two groups all be treated by 4 mentrual cycle. Detailed record the patients’clinical data. Headache index, scors. Through clinical research, hope to explore a new method for the treatment of headache, good curative effect, short course of treatment, less side effects, to provide new possibilities for the new use of the old, to provide a scientific basis for clinical.MethodsCollect 60 patients who suffered by headache duringe menstruation with liver-blood deficiency pattern, according to a randomized single blind principle divied the patients into two groups. Experimental group contain 30 patients give modified shoutai pills, and control group also contain 30 patients give siwutang decoction. Use Composite score methods, headache index, Self-Rating Anxiety Scale, Self-rating depression scale to explore the clinical effects of the medicine. Use β-EP、NO、ET-1\PGF2 α、PGE2 to explore the Mechanism of medicine.Results1 Modified Shoutai Pill group and Siwu Decoction control group patient age, disease duration, headache degree, and the general situation in before the start of the experiment, no statistical significance, that the two groups of patients with. (Table 1)2 Before the experiment, there was no statistical difference between the two groups of patients with headache and comprehensive score of headache index, which indicated that the two groups of patients had a comparable condition, (Table 2, table 3).3 Comprehensive efficacy (Table 4) display of modified Shoutai Pill group, 18 cases were cured; improved in 8 cases; 4 cases were ineffective; the total effective rate was 86.67%; Siwu Decoction group,10 cases were cured; improved in 12 cases; 8 cases were ineffective. The total effective rate was 73.33%.4. Modified Shoutai Pill group and Siwu Decoction control group in the clinical curative effect total efficiency were compared by statistical analysis of P < 0.05, which suggests a statistically significant. Hints of modified Shoutai Pill group the total curative effect is superior to that of Siwu Decoction. (Table 4)5. After treatment, the patients in the two groups in the experimental group, severe headache patients, moderate headache in 2 cases,18 cases of mild headache, no headache (10 cases), control group, severe headache,2 cases, 12 cases of moderate headache, mild headache in 15 cases, no one case of headache, after treatment in the two groups of headache degree compared with Ridit analysis u=2.059, P= 0.043. Prompt treatment, the patients in the two groups after the headache degree have obvious difference, the effect of experimental group was better than that of the control group. (Table 5)6. Treatment of patients in the experimental group before severe headache in 9 cases,18 cases of moderate headache,3 cases of mild headache, no cases of headache, treatment of severe headache patients, moderate headache in 2 cases,18 cases of mild headache, no headache (10 cases) and experimental group before and after treatment headache degree compared with Ridit analysis u=1.945, P=0.032. prompt treatment of patients in the experimental group before and after the headache degree difference, after treatment headache degree reduce. (Table 6)7. Before treatment in the control group, severe headache,7 cases, moderate headache in 19 cases,4 cases of mild headache, no cases of headache, after treatment, severe headache,2 cases,12 cases of moderate headache, mild headache in 15 cases, no headache in 1 case and control group before and after treatment of headache degree compared with Ridit analysis u=3.172, P=0.0473. prompt treatment of patients in the experimental group before and after the headache degree difference, after treatment of headache severity significantly reduced. (Table 7)8. Two groups of patients with headache score score a comprehensive comparison after statistical analysis, hints of modified Shoutai Pill in the experimental group before and after treatment score statistically significant ((P< 0.05); Siwu Decoction control group before and after treatment score compared with statistical difference (P< 0.05). Modified Shoutai Pill group and Siwu Decoction group treatment after scores were reduced. Two groups score between the two groups in the treatment of no significant difference before and after treatment two groups score differences (P< 0.05). Prompt treatment in experimental group were significantly lower than those of control group, the score, effect of the experimental group was better. (Table 8)9. The headache index of two groups of patients after statistical analysis, suggesting that experimental group before and after treatment score have significant difference ((P< 0.05); the control group before and after treatment score compared with significant difference ((P< 0.05). After treatment in the two groups the headache index decreased. Two sets of scores between groups no significant difference compared with before treatment, after treatment, two groups score difference ((P< 0.05). After treatment experimental group score lower than that of the control group, the score, effect of the experimental group was better. (Table 9)10. Two groups of patients with SDS quantity table table score (table 10) of two groups of patients with SDS score before the experiment comparison showed no significant difference t=0.378 P=0.797. After the experiment two groups comparison results have significant difference (t=2.215, P= 0.027). Two groups of patients with SDS scale score before the experiment, the comparison, the experimental group before and after the experiment comparison (t=3.791, P< 0.001) has significant difference; control group before and after the experiment (t=0.423, P= 0.618) without significant difference. Modified Shoutai Pill tips to improve the headache patients with depressive symptoms effectively.11. Modified Shoutai Pill group and Siwu Decoction group two groups of patients with SAS table score before the experiment comparison showed no significant difference. After the experiment there were significant differences. Two groups of patients with SAS scale score before the experiment, the comparison, the experimental group before and after experiment comparison (t=3.985 P< 0.001) there were significant differences; the control group before and after the experiment compared statistically difference without t=1.052 P=0.376. Tips of modified Shoutai Pill can relieve the headache patients with symptoms of anxiety. (Table 11)conclusion1 The traditional Chinese medicine in the treatment of liver blood deficiency type the headache, modified Shoutai Pill group the total efficiency was 86.67%, Siwu Decoction group the total efficiency was 73.33%. By statistical analysis of both have significant difference, suggesting that modified Shoutai Pill the total curative effect is superior to that of Siwu Decoction.2 Treatment were compared before and after the liver blood deficiency type the headache patients with headache index, comprehensive scoring method scoring headache, modified Shoutai Pill and Siwu Decoction has significantly reduced headache suggest related symptoms improved and modified Shoutai Pill treatment effect better.3. Modified Shoutai Pill and Siwu Decoction on liver blood deficiency type the headache patients with anxiety, depression, suggesting that both sides have different degrees of improvement in patients with anxiety, depression, modified Shoutai Pill effect is more obvious4. From the test results of two groups of patients with biochemical indicators, modified Shoutai Pill and Siwu Decoction two party 4 menstrual cycles, two groups of patients with plasma ET-1, PGF2 and PGF2 content of serum alpha alpha /PGE2 ratio were decreased, plasma beta epsilon P and serum PGE2, NO levels were increased. On the two party liver blood deficiency of the headache patients plasma beta -EP, ET-1, PGE2, serum PGF2, NO content of beneficial regulation, improve the headache in patients with endocrine abnormalities, but also to regulate the patients of neurohormones and vasoactive substances, so as to restore the head vasomotor balance and relieve headache. Experiments show that the modified Shoutai Pill can better regulate patients with neuroendocrine system.The headache is a common clinical treatment of gynecological diseases, similar to western medicine "menstrual migraine". Its pathogenesis is not fully understood, the disease commonly used sex hormone therapy of Western medicine, calcium channel blockers, sedative and analgesic, is symptomatic treatment, although there is a certain effect in a short period of time however, many adverse reactions, the recurrence rate is high, long-term effect is not ideal. Chinese medicine treatment of menstrual headache methods, traditional Chinese medicine, acupuncture and auricular plaster, foot and so on, are reflected in the characteristics of traditional Chinese medicine therapy, the curative effect in treating the disease. On the contrary, very unique, can relieve clinical symptoms, shorten the the treatment time, reduce treatment cost and other medicine can not be achieved, so the Chinese medicine treatment of menstrual headache has an extensive prospect of modified Shoutai Pill from the classic prescription of Shoutai Pill and easy for clinical workers to master, and the curative effect Obviously, it is a new way to develop new ideas for the classical prescriptions.