| Diabetes was belong to diabetes disease, traditional Chinese medicine thought the origin of disease was concerned with the weakness of body, innate deficiency, liking to eat the food which have much mastic and subcutaneous, sentiment out of tune, psyche overstress, intemperance in sexual life, weakness of semen and dryness of nephros. The change of diabetes was refer to basi-pathogenesi QI-blood diabetes was deficiency of both vital energy and yin, deficiency of both vital energy and yin to stop that ran though the disease. What is more,2-type diabetes yin-yang and five solid organs five viscera and six entrails were discovered, and signed it by deficiency of both vital energy and yin, basing on renal deficiency, blood stasis with dryness-heat. Zhu thought that the most of those who are suffering from the diabetes was type of deficiency of both QI and YIN, about 70 to 80 percent of these with promoting blood flow. Zhu-chenyu basic decoction was very appropriate to treat 2-type diabetes with type of deficiency of both QI and YIN. Used this recipe to treat 2-type diabetes would have a good curative effect in clinical.ObjectiveTo explore the possibility which was used Zhu-chenyu basic decoction for treating the diabetes with type of deficiency of both QI and YIN with syndrome of blood stasis and stagnation of blood by random and control methods.MethodsThe object of the investigation that was consistent with the standard of the traditional Chinese medicine of the diabetes with type of deficiency of both QI and YIN with syndrome of blood stasis and stagnation of blood, meanwhile, also was consistent with the standard of diabetes diagnosed by western doctor. Divided two groups in random, one group was set to take the medicine of Zhu-chenyu basic decoction combined drug for invigorating blood circulation and eliminating stasis, the other group was set to take the medicine of the Liuweidihuangwan decoction combined with the drug for invigorating blood circulation and eliminating stasi. To observe the synthetic curative effect,the score of the traditional Chinese physician symptom,blood sugar and glycosylated hemoglobin, then to evaluate the validity and the safety of the Zhu-chenyu basic decoction. Statistical methods:we usedχ2 test for the classify data, used Wilcoxon rank sum test for the ranked data, used t test or Wilcoxon rank sum test to test two specimen mean and used t test or Wilcoxon rank sum test or test to compare self-comparison.ResultsFinally, there were 70 cases which have been met the exclusion criteria in the analysis, the Zhu-chenyu basic decoction treatment group and the Liuweidihuangwan decoction combined with the drug for invigorating blood circulation and eliminating stasis control group each have 35 cases. The average patient age was 42.7±5.9 years; at the same ratio of men and women; average duration was 36.8±7.2 months. According to the conclusion of the clinical treatment, there was 77.14 percent of patient has the obvious effect which used Zhu-chenyu basic decoction, and 54.2 percent of patient has the obvious effect in the control group, there was statistical difference between two groups, which indicating that it has significant effect for treating diabetes. According to the clinical symptom, dry mouth, spontaneous or night sweats, shortness of breath lazy words, five upset hot, insomnia, weak waist and more urinary symptoms were improved in both groups, while the treatment group sleepy fatigue and heart palpitations symptoms after treatment significantly improved, it was indicated that has significant effect in treatment group. According to the changeable score of the clinical symptom, each group has significant effect in dry mouth, burning sensation of five centres, palpitation, weak waist, weak waist and more urinary symptoms; but the treatment group was better than the control group for improving mouth, spontaneous or night sweats, and shortness of breathe lazy words. The Zhu-chenyu basic decoction group can effectively reduce the laboratory of three indicators (P<0.05), while the control group only can reduce postprandial blood glucose. There was statistically significat (P<0.05); it can be considered hypoglycemic side effects than the control group. Safety testing showed that the blood routine test, urine routine test, stool routine test, liver and kidney functions and normal ECG were normal after treatment. It indicated that the Zhu-chenyu basic decoction was safety in the clinical application.ConclusionAfter treatment, it was found that Zhu Chen basic Decoction had its unique advantages and feature in improving clinical symptoms, so it has significant effect in the diabetes of deficiency of both vital energy and yin with blood stasis type. Further more, it was safe and effective and has the potential of further development. |
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