Research On Glucose Concentration Detection Based On Artificial Metasurfac

In the past decade,the prevention and treatment of diabetes and its complications have received extensive attention,but the existing prevention and treatment methods cannot completely avoid the occurrence of complications.Intensive hypoglycemic therapy based on Continuous Glucose Monitoring(CGM)will hopefully alleviate the symptoms of complications and delay the onset of complications.However,due to the current bottleneck of CGM cannot have both features of non-invasive and high-precision,this treatment scheme has not yet benefited the public.Based on this,this paper introduces an artificial meta-surface into glucose detection,and combines its unique electromagnetic characteristics to achieve near-field focusing of the electromagnetic field reflected by the object to be measured.Near field focusing can improve the compactness of the detection device while also improving the sensitivity and accuracy of glucose solution concentration detection.Based on the generalized Snell’s law and phase compensation theory,three artificial meta-surface structures,namely,a "straight" shaped structure,a dual even single ring structure,and a dual even double ring structure,have been designed for the detection of glucose solutions.The processing tests of the dual even single ring structure have been carried out.The experimental results show that the sensitivity of the glucose solution detection method proposed in this paper is 0.03 Vm-1/mmol L-1,with an average absolute relative error of 7.0%,and a maximum error of 9.6%,the validity of the glucose solution detection proposed in this article was verified.The research in this article has accumulated a theoretical and technical foundation for achieving non-invasive and highprecision CGM.The main work includes the following four parts:(1)The development history and research status of artificial meta-surface were investigated,and blood glucose detection methods at home and abroad were summarized.The basic principles of various non-invasive blood glucose detection methods were elaborated,and the existing problems and shortcomings were analyzed.(2)The basic theory of artificial meta-surface is described,and the near-field focusing principle based on artificial meta-surface is presented.The comparison between the non focusing scheme and the near-field focusing scheme demonstrates the feasibility of the nearfield focusing scheme of artificial meta-surface for improving the accuracy of glucose detection.(3)Based on the designed single even single ring and single even double ring artificial meta-surface cell structures,the influence of cell structure size on compensation phase was studied.Then,single even single ring and single even double ring artificial meta-surfaces are designed,and the effects of the flatness of the compensation phase curve and the number of elements on the focusing characteristics are analyzed.Accordingly,three types of artificial meta-surface unit structures for glucose concentration detection,namely,"Gen" shaped,dual even single ring shaped,and dual even double ring shaped,were designed.(4)An experimental test was conducted on a dual even single annular artificial metasurface.A glucose solution of 1-17 mmol/L was placed in the dual even single annular artificial meta-surface for experimental measurement,detection accuracy,and error analysis to verify the effectiveness of the near field focusing scheme for the artificial meta-surface proposed in this article.