| Objective:The clinical study on the treatment of functional hypothalamic amenorrhea caused by dieting(spleen and kidney deficiency syndrome)by the method of invigorating the spleen and tonifying the kidney combined with Fenmutong combined with the diet structure intervention was conducted to observe the treatment effect and improve the clinical symptoms of patients with functional hypothalamic amenorrhea,providing a new idea for the treatment of functional hypothalamic amenorrhea by combining traditional Chinese and western medicine.Materials and methods:Select 63 patients who met the diagnostic criteria of functional hypothalamic amenorrhea(spleen and kidney deficiency syndrome)caused by dieting from September2020 to December 2022 in the Department of Obstetrics and Gynecology of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.According to the method of drawing lots,the patients were randomly divided into the control group(n=31)and the observation group(n=32).Both groups were treated with Fenmotone combined with dietary intervention.The observation group was treated with Peitu Guyuan Formula on the basis of the control group.Before and after treatment,the patient’s body mass index,menstrual cramps,the number of menstrual cramps after drug withdrawal,the score of TCM syndrome and the score of eating disorders examination scale(EDE-Q)were recorded;The curative effects of the two groups were analyzed and evaluated with statistical software.Results:1.General comparison: there were no significant differences in age,BMI,FSH and LH hormone levels before treatment,TCM syndrome scores and eating disorder examination scale(EDE-Q)scores between the two groups(P>0.05),indicating that the two groups were comparable.2.Comparison of menstrual cramping after discontinuation of treatment in two groups of patients after treatment,the results of statistical analysis showed that the effective rate of menstrual cramping after discontinuation of treatment in the control group(80.0%),the effective rate in the observation group(93.3%),and the frequency of menstrual cramping after discontinuation of treatment in two groups were statistically significant(P < 0.05).3.Comparison of body mass index(BMI): before and after treatment,the BMI of both patients was elevated,and the within group difference was statistically significant(P <0.05);The improvement of BMI after treatment in the observation group was more obvious than that in the control group,and the difference between groups was statistically significant(P<0.05);When comparing the follow-up period with the post-treatment period,BMI increased in both groups,and the within group difference was statistically significant(P<0.05);The BMI of the observation group during the follow-up period increased significantly compared with that of the control group,and the difference between the groups was statistically significant(P<0.05).4.Comparison of changes in FSH and LH levels: comparing before and after treatment,FSH and LH levels improved in both groups,and the within group differences were statistically significant(P<0.05);FSH and LH levels in the observation group increased significantly compared with the control group after treatment,and the differences between groups were statistically significant(P<0.05);In the comparison between the follow-up period and the post-treatment period,FSH and LH levels decreased in both groups,and the within group differences were statistically significant(P<0.05);FSH and LH levels in the observation group during the follow-up period were comparable to those of the control group,with statistically significant differences between the groups(P<0.05).5.Comparison of TCM syndrome score: Compared before and after treatment,the TCM syndrome score of both patients decreased,and the difference between groups was statistically significant(P<0.05);The TCM syndrome scores decreased more significantly after treatment in the observation group than in the control group,and the difference between the groups was statistically significant(P<0.05);When comparing the follow-up period with the post-treatment period,TCM syndrome scores increased in both groups,and the within group differences were statistically significant(P<0.05);The TCM syndrome scores of the observation group during the follow-up period were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).6.Comparison of eating disorder examination scale(EDE-Q)scores: the eating disorder examination scale(EDE-Q)scores of the two groups were decreased,and the within group differences were statistically significant(P<0.05);The eating disorders examination scale(EDE-Q)scores of the observation group after treatment decreased more significantly than those of the control group,and the differences between the groups were statistically significant(P<0.05).When comparing the follow-up period with the post-treatment period,the eating disorder examination scale(EDE-Q)scores of both patients increased,and the within group differences were statistically significant(P<0.05);The eating disorders examination scale(EDE-Q)scores of the observation group during the follow-up period were significantly(P<0.05)lower than those of the control group.7.Safety analysis: there were no adverse reactions and side effects in the two groups of treatment methods.Conclusion:1.The combination of spleen and kidney tonifying method and fenmodone can improve the menstrual flow of patients with functional hypothalamic amenorrhea(spleen and kidney deficiency)caused by dieting and increase the body mass index,FSH and LH hormone levels of patients with functional hypothalamic amenorrhea(spleen and kidney deficiency)caused by dieting.2.The combination of Spleen and Kidney tonifying method and fenmodone can reduce the TCM symptom score and eating disorder score of patients with functional hypothalamic amenorrhea(Spleen and Kidney deficiency syndrome)caused by dieting.This was mainly reflected in the alleviation of symptoms such as soreness and weakness of the waist and knees,lack of food and sluggishness after treatment,and the reduction of patients’ control over diet and concerns about eating,body shape and weight.3.The combination of spleen and kidney tonifying method and fenomentone was superior to fenomentone alone in improving the long-term outcome of patients with functional hypothalamic amenorrhea(spleen and kidney deficiency)caused by dieting.4.The combination of Spleen and Kidney tonifying method and Fentanyl for patients with functional hypothalamic amenorrhea caused by dieting(evidence of deficiency of both spleen and kidney)has no obvious adverse effects,no drug toxic side effects and is safe and can be an effective treatment for this disease. |
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