Study On The Correlation Between TCM Syndrome Types And The Degree Of Coronary Artery Stenosis In Patients With Coronary Heart Disease Combined With H-type Hypertensio

Purpose:In this study,patients diagnosed with primary hypertension and coronary heart disease were retrospectively analyzed.According to the results of blood homocysteine(HCY),TCM syndrome types and coronary angiography(CAG),the distribution rule of TCM syndrome types in CHD patients with H-type hypertension and the correlation between TCM syndrome types and coronary artery disease and Hcy levels were preliminarily explored and analyzed to reveal the relationship,providing a reference for the next step of targeted prediction,diagnosis,treatment and prognosis evaluation of CHD patients with H-type hypertension.Material and method:A total of 121 patients with coronary heart disease and primary hypertension who underwent hospitalization and underwent CAG examination at the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 2021 to November 2022 were selected as the study subjects,and relevant case information was collected.They were grouped according to HCY levels,angiographic findings,and TCM syndromes.Finally,the experimental data were collated and compared to explore and analyze the distribution characteristics of TCM syndrome types,the characteristics of coronary artery disease and the differences in blood homocysteine levels in each group and the correlation between the three,so as to obtain a preliminary conclusion.Results:1.Comparison of basic information: Age、BMI and LDL-C of the CHD combined with H-type hypertension patients were higher than those of the CHD combined with ordinary hypertension patients,and the other physical and chemical indexes such as Tg,TC,HDL-C had no significant difference(p > 0.05).2.There were significant differences between the CHD combined with H-type hypertension group and the CHD combined with ordinary hypertension group in two-vessel disease,Gensini score and blood stasis syndrome(p < 0.05),but there was no significant difference in the degree of stenosis(p > 0.05).3.The number of pathological changes in CHD combined with H-type hypertension group : the blood stasis syndrome group was mainly composed of one vessel;In the group of turbid phlegm and deficiency of qi,there were mainly 3 vessels;The degree of stenosis: the blood stasis syndrome group and phlegm turbidity syndrome group were mainly moderate stenosis,while the qi deficiency syndrome group were mostly moderate and severe stenosis.4.There was statistically significant difference in Gensini score in CHD combined with H-type hypertension group(P=0.0025),of which phlegm turbidity syndrome group>qi deficiency syndrome group>blood stasis syndrome group.5.The distribution of blood homocysteine level between TCM syndromes is mainly phlegm-turbid syndrome group and blood stasis syndrome.After one-way analysis of variance,P > 0.05,there was no significant difference in Hcy levels between the syndromes by multiple comparisons between groups.6.There are some differences in Hcy levels among TCM syndromes in CHD with H-type hypertension group.A value of p < 0.05 was considered statistically significant.Conclusion:1.This study found that the distribution of traditional Chinese medicine syndrome types in patients with CHD combined with H-type hypertension has its own pattern,with the majority of patients with phlegm turbidity syndrome and blood stasis syndrome,and the Hcy levels of patients with phlegm turbidity syndrome and blood stasis syndrome are in a relatively high stage of increase.2.This study shows that patients with CHD combined with H-type hypertension have more involvement in coronary artery disease,with severe changes in coronary artery disease.The relationship between traditional Chinese medicine syndrome types and phlegm turbidity syndrome is the closest.