Clinical Observation On The Treatment Of Chronic Hepatitis B Of Spleen And Kidney Yang Deficiency Type With Jiawei Dabu Shen Tang Combined With Entecavi

Obj ective:The subjects of this study were patients with chronic viral hepatitis B who manifested as symptoms of spleen and kidney yang deficiency,and by observing the clinical efficacy and safety of adding flavored Dabushen Decoction combined with entecavir,this paper provides useful ideas for the clinical combination of traditional Chinese and Western medicine for the prevention and treatment of chronic hepatitis B.Methods:From September 2021 to January 2023,72 patients with chronic hepatitis B were collected in the inpatient and outpatient departments of hepatology,Hengyang Hospital,Hunan University of Chinese Medicine,and were randomly divided into 36 cases in the treatment group and 36 cases in the control group.After enrollment,the treatment group was treated with entecavir+flavored Dabushen Decoction,and the control group was treated with entecavir.The 12-week course was a course of treatment,and two courses were observed continuously in both groups.Before and after treatment,the two groups of patients were collected with medical syndrome score,liver function index,hepatitis B virus nucleic acid quantification,E antigen negative rate,liver fibrosis index,safety index and other data to determine the effect and safety of drug treatment.Results:In this trial,72 patients were planned to be included,and 62 patients were finally completed,including 30 patients in the treatment group and 3 2 cases in the control group.The results of the analysis are as follows:(1)There was no significant difference in age,sex and course of disease before treatment between the two groups(P>0.05),which was comparable together.(2)In terms of TCM clinical syndrome points,the TCM syndrome points in the treatment group were significantly reduced(P<0.05).The effective rates of the two groups after 12 w treatment were 66.6 7%and 3 1.25%,respectively,and the effective rates of the two groups after 24 w treatment were 83.3 3%and 50.00%,respectively,and there were significant statistical differences between the two groups(P<0.01).The efficiency of the treatment groups was more significantly improved in the treatment group of 12w and 24 w,and there were significant differences in liver function and viral nucleic acid quantity in the treatment group and control group(P<0.01),and there were significant differences in liver function and viral nucleic acid quantity of 12w and 24w indexes between the treatment group and the control group(P<0.05),there was no significant before and after comparison between the control group(P>0.05),within the treatment group within the 12w group(P>0.05),and before and after 24w(P<0.05),and there was no significant difference between the treatment group and the control group before and after treatment(P>0.05).(3)During the treatment,there were 2 adverse reactions in the treatment group and 1 adverse reactions in the control group,and the adverse reaction rates of the two groups were not comparable after relevant symptomatic treatment(P>0.05).Conclusion:The treatment group is superior to the control group in red ucing clinical symptoms,improving treatment response rate,improving quality of life and restoring liver function,which is worthy of further promotion and research.