| OBJECTIVE:To observe the efficacy and safety of Chaishao Duonangyin combined with auricular point pressing pills in the treatment of Polycystic ovary syndrome(PCOS)with kidney deficiency and liver depression.METHODS:From June 2021 to September 2022,PCOS patients who met the inclusion criteria were selected from the Department of Gynecology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences.They were divided into observation group and control group according to the random envelope method.Among them,the control group was treated with Chaishao Duonangyin,and the observation group was treated with auricular point pressing pills on the basis of the treatment of the control group,for a total of 24 weeks.The basal body temperature(BBT)biphasic rate,BBT rate,cycle biphasic rate,menstrual cycle,menstrual period,menstrual volume score,TCM symptom score,female hormones(estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),prolactin(PRL),progesterone(P),testosterone(T)),fasting insulin(FINS),fasting plasma glucose(FG),homeostasis Model assessment-insulin resistance index(HOMA-IR),Self-Rating Anxiety Scale(S AS)score,SelfRating Depression Scale(SDS)score,liver and kidney function and other items were compared between the two groups before and after treatment.The number of cases with adverse reactions such as diarrhea,nausea,and vomiting during the treatment was recorded and the incidence of adverse reactions in the two groups was calculated.Statistical analysis was performed on the results.RESULTS:1.A total of 60 patients were included in this study,including 30 cases in the observation group and 30 cases in the control group.All observations were completed,the data were complete,and included in the statistics.2.After treatment,5 cases were pregnant in the observation group,and 25 of the 30 patients had biphasic BBT,and the rate of biphasic BBT was 83.3%.A total of 169 menstrual cycles were observed,and biphasic BBT occurred 100 times,and biphasic BBT occurred 100 times.The rate is 59.2%.There was 1 pregnancy in the control group,and 22 of the 30 patients had biphasic BBT,with a biphasic BBT rate of 73.3%.A total of 177 menstrual cycles were observed,and biphasic BBT occurred 75 times,with a biphasic BBT rate of 42.4%.After treatment,there was no significant difference in the BBT biphasic rate between the two groups(P>0.05);the BBT cycle biphasic rate in the observation group was significantly better than that in the control group(P<0.01).3.The menstrual cycle score indicates the degree of abnormal menstrual cycle,and the higher the score,the longer the cycle.Compared with before treatment,the menstrual cycle scores in the observation group decreased significantly in the second,third,fourth,fifth,and sixth cycles of treatment(P<0.01);the menstrual cycle scores in the control group decreased significantly in the third,fourth,fifth,and sixth cycles of treatment(P<0.01).After treatment,the menstrual cycle score of the observation group was lower than that of the control group(P<0.05).The menstrual period score indicates the degree of menstrual period abnormality,and the higher the score,the higher the degree of menstrual period abnormality.Compared with before treatment,the menstrual period score of the observation group decreased in the fifth and sixth cycles of treatment(P<0.05),the menstrual period score of the control group decreased in the fourth,fifth,and sixth cycles of treatment(P<0.05).There was no significant difference in the menstrual period score between the two groups after treatment(P>0.05).The menstrual flow score indicates the degree of abnormal menstrual flow,and the higher the score,the higher the degree of abnormal menstrual flow.Compared with before treatment,the menstrual flow scores of the observation group decreased in the first,second,third,fourth,fifth and sixth cycles of treatment(P<0.05);the scores of the control group decreased in the second,third,fourth,fifth and sixth cycles of treatment(P<0.05).There was no significant difference in menstrual flow scores between the two groups after treatment(P>0.05).4.The TCM symptom score indicates the severity of the symptoms,and the higher the score,the more severe the symptoms.Compared with before treatment,the scores of TCM symptoms in the observation group were significantly reduced in the first,second,third,fourth,fifth,and sixth cycles of treatment(P<0.01);the scores of TCM symptoms in the control group were significantly reduced in the second,third,fourth,fifth,and sixth cycles of treatment(P<0.05).After treatment,the TCM symptom score of the observation group was lower than that of the control group(P<0.05).5.Compared with before treatment,the levels of LH and T in the two groups decreased after treatment(P<0.05),and the levels of FSH,E2,P,and PRL had no significant difference(P>0.05).After treatment,there were no significant differences in FSH,LH,E2,P,T,and PRL between the two groups(P>0.05).6.Compared with before treatment,the levels of FINS and HOMA-IR in both groups decreased significantly after treatment(P<0.01).After treatment,there was no significant difference in the levels of FINS,FG,and HOMA-IR between the two groups(P>0.05).7.The S AS score indicates the severity of anxiety,and the higher the score,the more severe the anxiety.Compared with before treatment,the SAS scores of the observation group and the control group were significantly lower in the third and sixth cycles of treatment(P<0.01).Compared with the two groups after treatment,the SAS score of the observation group was significantly lower than that of the control group(P<0.01).The SDS score indicates the severity of depression,and the higher the score,the more severe the depression.Compared with before treatment,the SDS scores of the observation group and the control group were significantly lower in the third and sixth cycles of treatment(P<0.01).After treatment,there was no significant difference in SDS score between the two groups(P>0.05).8.Compared with before treatment,there was no significant difference in ALT,AST,Cr,and BUN between the two groups after treatment(P>0.05),and they were all within the normal range.After treatment,there was no significant difference between the two groups(P>0.05).There were no adverse reactions reported in the observation group and the control group.No serious adverse events occurred in the two groups.CONCLUSION:1.Chaishao Duonangyin combined with auricular point pressing pills in the treatment of PCOS with kidney deficiency and liver depression can improve ovulation,promote pregnancy,regulate menstrual cycle,menstrual period,and menstrual volume,relieve symptoms,anxiety,and depression,regulate reproductive hormone levels,and correct glucose metabolism disorders.Among them,in terms of improving ovulation,regulating menstrual cycle,reducing symptoms and anxiety,the curative effect of Chaishao Duonangyin combined with ear point pressing pills is better than that of traditional Chinese medicine alone.2.Chaishao Duonangyin combined with auricular point pressing pills has certain safety in the treatment of PCOS with kidney deficiency and liver depression. |
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