| Purpose: To explore the curative effect of Fufang Huangqi Decoction on type I ～ III myasthenia gravis of spleen and kidney deficiency type by observing the reduction of basic Western medicine,the improvement of clinical symptoms and the effective rate of patients with type I ～ III myasthenia gravis before and after treatment.Materials and methods: From September 2019 to September 2021,70 patients with type I ～ III myasthenia gravis diagnosed as spleen and kidney deficiency in the outpatient department of the Affiliated Hospital of Liaoning University of traditional Chinese medicine were collected,all of whom had signed informed consent.There were 32 males and 38 females.The ratio of male to female was 1:1.19.The age ranged from 19 to 75 years.There were 27 cases of type I,22 cases of type II and 21 cases of type III of MGFA.The course of disease was 18 to 126 months at the time of enrollment.The patients were randomly divided into control group and experimental group,with 35 patients in each group.The control group was treated with bromopyrimidine tablets combined with prednisone acetate.The dosage of bromopyrimidine tablets was 222.43±115.88 mg/day and prednisone acetate was 34.54±13.88mg/day;The experimental group was treated with bromopyrimidine tablets,prednisone acetate and Fufang Huangqi decoction.The dosage of bromopyrimidine tablets was243.43 ± 157.70 mg/day and prednisone acetate was 35.21 ± 13.60 mg/day;The dose of Western medicine increased and decreased with the patient’s condition,and the course of treatment was 6 months.The general data of patients,the dosage of bromopyrimidine tablets and prednisone acetate at 0,3 and 6 months,the absolute score,relative score and effective rate of myasthenia gravis were counted.Adopt spss26.0 software for statistical analysis.Result:1.There was no significant difference in the effective rate between the two groups at 3months(P > 0.05),but there was significant difference in the effective rate at 6 months(P <0.05).At 6 months,the total effective rate of the experimental group was 94.29% and that of the control group was 80.00%;2.Three months after enrollment,the dosage of bromepyramine tablets in the experimental group was 162.86±139.82 mg/day,the dosage of prednisone acetate was 21.43±10.25 mg/day,the dosage of bromepyramine tablets in the control group was 195.86±126.86 mg/day,and the dosage of prednisone acetate was 27.64 ± 12.44 mg/day;Six months after enrollment,the dosage of bromepyramine tablets in the experimental group was 113.14±81.70 mg/day,the dosage of prednisone acetate was 13.36±9.70 mg/day,the dosage of bromepyramine tablets in the control group was 163.71 ± 112.39 mg/day,and the dosage of prednisone acetate was22.82 ± 13.17 mg/day.At 3 months after enrollment,the dosage of Western Medicine(bromopyrimidine tablets and prednisone acetate)in the two groups was significantly lower than that at 0 months after enrollment(P < 0.05),and at 6 months after enrollment,the dosage of Western medicine in the two groups was significantly lower than that at 3 months after enrollment(P < 0.05);There was significant difference in the dosage of Western medicine between the two groups at 3 and 6 months after admission(P < 0.05),and there was also significant difference in the amount of Western medicine reduced per capita between the two groups(P < 0.05).The amount of Western medicine reduced per capita in the experimental group was higher than that in the control group;3.At 3 months of enrollment,the absolute score of the experimental group was 21.43±7.47 and that of the control group was 23.57±10.02.There was significant difference between the two groups(P < 0.05).At 6 months of enrollment,the absolute score of the experimental group was 10.03±5.57 and that of the control group was 13.94±8.10,The absolute scores of the two groups were significantly higher than that at 3 months(P < 0.05);There was also significant difference in absolute score between the two groups at 3 and 6 months(P < 0.05);4: Three months after enrollment,two patients(2 / 35,5.71%)in the control group had adverse reactions,which were gastrointestinal reactions.There were no adverse reactions in the experimental group,and there was no significant adverse reactions between groups(P > 0.05);Six months after enrollment,six patients(6 / 35,17.14%)in the control group had adverse reactions,four patients(4 / 35,11.43%)had gastrointestinal reactions,one patient(1 /35,2.86%)had elevated blood glucose and one patient(1 / 35,2.86%)had weight gain.There were no adverse reactions in the experimental group,and the difference of adverse reactions between the groups was statistically significant(P < 0.05).Conclusion:1.Fufang Huangqi decoction can effectively help patients with myasthenia gravis reduce the dosage of basic Western drugs(bromopyrimidine tablets and prednisone acetate);2.Fufang Huangqi decoction can improve the clinical symptoms of myasthenia gravis in 3months;3.The efficacy of combined traditional Chinese and Western Medicine(Fufang Huangqi decoction combined with bromopyrimidine tablets and prednisone acetate)in the treatment of myasthenia gravis is more significant than that of only basic Western Medicine(bromopyrimidine tablets and prednisone acetate);4.Fufang Huangqi decoction can effectively reduce the occurrence of adverse reactions caused by basic Western medicine in the treatment of myasthenia gravis for 6 months. |
PDF Full Text Request