| Objective: The clinical observation of Chinese medicine combined with BILT liver disease treatment instrument to treat hepatitis B related chronic acute liver failure,discuss its clinical efficacy and safety,and provide evidence-based medical evidence for the treatment of HBV-ACLF.Methods: 1.Clinical research adopts a retrospective queue research method,and selects the case of the first affiliated hospital of Hunan University of Traditional Chinese Medicine from January 2021 to December 2021 diagnosed as a case of hepatitis B related chronic acute liver failure.The 23 cases of the BILT liver disease therapy instrument are the control group,and the 33 cases of 33 cases of the use of the BILT liver disease treatment instrument are the treatment group.Liver protection enzymes,anti-infection,regulating intestinal flora and other symptomatic support treatment.According to the patient’s condition,it appropriately apply plasma and albumin nutrition support treatment,maintain hydrolysis and acid-base balance,and actively prevent complications.Artificial liver plasma replacement treatment.In the treatment of traditional Chinese medicine,the fourth diagnosis was combined,and the syndrome of Chinese medicine decoction was treated.On the basis of giving the control group as active treatment,the treatment group uses BILT(DSG-III Hangzhou Divine Medical Device Co.,Ltd.)liver disease treatment instrument auxiliary treatment.2.The relevant indicators that record the first examination after the patient were admitted to the hospital were the baseline indicators(that is,the relevant indicators before treatment),and recorded the relevant clinical symptoms of the second and fourth week after the patient admitted to the hospital and calculated the accuracy of traditional Chinese medicine syndrome and liver function(Alb,TBIL,AST,Alt),coagulation function(PTA),blood conventional(WBC,PLT),infection indicators(CRP,IL-6,PCT),Meld scores,etc.The indicators conduct statistical analysis and comparison.Results:(1)Mortality and total efficiency: In the second week after treatment,neither patients died in the treatment group and control group.The total effective rate of treatment was 69.7%and 56.52%,respectively.The difference between the comparison between the group is statistically significant(P = 0.043 <0.05);the total mortality rate of the treatment group and the control group was 6.06%and 13.04%during the 4th week after treatment.Although the mortality of the treatment group is lower than the control group,there is no statistically significant difference between the two groups(P = 0.671>0.05).The total effective rates of the treatment group and control group were 88.89%and62.7%,respectively.The treatment group was significantly better than the control group,and the differences between the two groups were statistically significant(P = 0.006<0.05).(2)Plot points for traditional Chinese medicine certificate: After treatment,the average level of Chinese medicine certificate points of the two groups of patients decreased significantly compared with the previous period;compared with the control group at the same time,the average of the Chinese medicine certificate of the TCM certificate in the second and fourth week of the treatment group was excellent average.In the control group,the difference between the group is relatively statistically significant(P <0.05).(3)Liver function(ALB,TBIL,AST,ALT): The average level of ALB of the two groups of patients after treatment has increased slowly,but compared with the control group at the same time,there is no statistically significance in the group(P> 0.05);treatment The level of TBIL in the last two groups has decreased significantly.Compared with the control group during the same period,the TBIL decrease level in the second and fourth week treatment group is better than the control group,and the difference between the group is relatively statistically significant(P <0.05);After the treatment,the level of AST of the two groups of patients decreased significantly.Compared with the control group during the same period,the AST decrease level in the second and fourth week of the treatment group was better than the control group,and the difference between the group was relatively statistically significant(the group was more statistically significant(the group was more statistically significant(P <0.05);After the treatment,the level of ALT in the two groups of patients decreased significantly.Compared with the control group during the same period,the ALT decrease level of the treatment group was better than the control group.0.05).(4)Coagulation function: After the treatment,the level of PTA in the two groups of patients has increased.Compared with the control group at the same time,the difference between the group is relatively significant(P> 0.05).(5)Blood routine(WBC,PLT): After the treatment,the WBC of the two groups of patients decreased average from the baseline.Compared with the control group at the same time,there was no statistically significance between the groups(P> 0.05).After the treatment,the PLT of the two groups of patients had fluctuations,and the overall level of the baseline decreased.Compared with the control group during the same period,there was no statistically significance(P> 0.05).(6)Infection indicators(CRP,IL-6,PCT): After the treatment,the CRP levels of the two groups of patients have fluctuated and fluctuated,and the levels of the two groups of CRP are ultimately declined.Compared with the control group during the period,there is no difference between the group.Statistical significance(P> 0.05);comparison of IL-6 levels after treatment: both IL-6 levels have fluctuated and fluctuated,and the levels of the two groups of IL-6 eventually decreased.Compared with the control group at the same time,the group between the group was compared with the group,and the group was compared with the group.The difference is not statistically significant(P> 0.05);after treatment,the PCT levels of the two groups of patients have fluctuated and fluctuated,and the levels of the two groups of PCT are ultimately declined.Compared with the same period of the control group at the same period after treatment,treatment is compared with the control group.The PCT level of the group is lower than the control group,and the difference between the group in the fourth week is statistically significant(P <0.05).(7)Meld score: After the treatment,the MELD scores of the two groups of patients have decreased significantly compared with the previous.Compared with the control group at the same time,the level of the MELD of the treatment group is lower than the control group.(P = 0.02 <0.05).(8)Safety indicators: No adverse reaction is found,and its short-term application is safe and reliable.Conclusion:(1)Based on the comprehensive treatment of Western Medicine Internal Medicine+ Chinese Medicine Syndrome Differential Treatment,combined with the BILT(DSG-III)liver disease therapy instrument can better improve the liver function(reduce the level of TBIL/AST),reduce the waiting points for traditional Chinese medicine,alleviate relief Clinical symptoms,improve the total efficiency of treatment,improve short-term prognosis and quality of life;(2)Based on the comprehensive treatment of Western Medicine,Chinese medicine syndrome differentiation theory combined with BILT(DSG-III)hepatic disease therapy instrument-III)Hepatitis Treatment instrument has certain clinical effects in the treatment of hepatitis B related chronic acute liver failure,which is worthy of promoting in clinical applications;(3)The BILT(DSG-III)hepatic disease therapy instrument did not occur during the clinical application,and its short-term application was safe and reliable. |
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