Study On The Correlation Between The Five Internal Organs Syndromes Of Diabetic Nephropath

ObjectiveDiabetic nephropathy is critically ill in the advanced stage and endangers the health and life of patients.At present,Western medicine has limited methods for treating diabetic nephropathy,mainly for the purpose of delaying the progression of diabetic nephropathy.The advantages of traditional Chinese medicine in treating diabetic nephropathy are outstanding,and the curative effect is remarkable.Since ancient times,traditional Chinese medicine has the treatment idea of "no disease first prevention,disease prevention and prevention".Each disease has a specific law of transformation,study the syndrome of diabetic nephropathy and the change of disease position,explore the order of diabetic nephropathy to damage the viscera,help the clinical treatment of diabetic nephropathy,and achieve the purpose of "preventing disease prevention".Thereby further improving the efficacy of traditional Chinese medicine and delaying the progression of diabetic nephropathy.MethodsThe clinical data of 219 patients with diabetic nephropathy were collected clinically,including 71 patients with early stage,74 patients with intermediate disease,and 74 patients with advanced disease.The patient data were processed by SPSS20.0 statistical software.The measurement data were expressed by frequency and percentage.Chi-square test was used to determine whether there were differences in the number of symptoms,symptoms,and visceral lesions in the early,middle,and late stages,and whether there were differences in the number of early and middle,middle,and late,early and late visceral syndromes.Taking the visceral syndrome as the dependent variable(assignment 1=yes,0=no),gender(assignment 0=male,1=female),age,red blood cells,white blood cells,hemoglobin,total protein,creatinine,glomerular filtration rate,Triglyceride and 24-hour urine protein were quantified as independent variables.Logistic regression analysis was performed.The variables were introduced by entry method.The model test results were statistically significant(P<0.05).Results1.The changes of syndromes in early,middle and late stages of diabetic nephropathy were statistically significant for liver(P 0.018<0.05)and kidney(P 0.008<0.05),while the changes of syndromes in lung,heart and spleen were not statistically significant.The changes of syndromes in early and middle phases were statistically significant for kidney(p=0.044<0.05),but not for lung,heart,liver and spleen.The early and late stages of syndrome changes were statistically significant for liver(P 0.015<0.05)and kidney(P 0.002<0.05),but there was no statistical significance for lung,heart and spleen syndrome changes.There was no statistical significance in the changes of liver,lung,heart,spleen and kidney syndromes in the middle and late stages.2.There were 33,31 and 20 patients with liver syndrome in early,middle and late stages of diabetic nephropathy,accounting for 46.47%,41.89%and 27.03%of the total number of patients in each stage respectively.The number of liver syndrome gradually decreased.The number of patients with early,middle and late stage renal syndrome of diabetic nephropathy is 24,41 and 51 respectively,accounting for 33.80%,55.41%and 68.92%of the total number of patients in each stage respectively.The number of renal syndrome is gradually increasing.3.Pulmonary syndrome has a correlation with white blood cells(P is 0.006<0.05),and its OR value is 4.545,that is,with the increase of white blood cells,the incidence of pulmonary syndrome is higher.Cardiac syndrome has a correlation with serum total protein(P is 0.028<0.05),and its OR value is 0.469,that is,the lower the total protein,the higher the incidence of ventricular syndrome.Renal syndrome has a correlation with age(P=0.005<0.05)and 24-hour urine protein quantitation(P is 0.006<0.05).The OR value of age is 1.052,that is,the older the kidney,the higher the incidence of renal syndrome.high.The OR value of 24-hour urine protein quantitation was 1.655,which means that the probability of occurrence of renal syndrome increases with the increase in 24-hour urine protein quantitation.4.the symptoms of diabetic nephropathy patients in the early,middle and late stages showed statistically significant changes in spontaneous perspiration(p 0.012<0.05),cardiothoracic vexation heat(p 0.035<0.05),impatience and irritability(p 0.003<0.05),dark complexion(p 0.032<0.05),and edema of face and foot(p 0.000<0.05).5.The changes of the number of visceral concurrent diseases in diabetic nephropathy patients in early,middle and late stages have P values>0.05,with no statistical significance.Conclusions1.Diabetic nephropathy may be transmitted from liver to kidney from early to late stage.2.In the early stage of diabetic nephropathy,attention should be paid to the treatment of liver system syndromes.The treatment methods include clearing liver,purging liver,soothing liver and nourishing liver.In the late stage,attention should be paid to the protection of kidney yang to prevent deficiency of yang qi and further aggravate the disease.3.The early,middle and late stages of diabetic nephropathy with lung qi deficiency syndrome are obvious.Attention should be paid to tonifying lung qi,which can delay the progress of diabetic nephropathy and make healthy qi sufficient to prevent invasion of external pathogens.4.In diabetic nephropathy,spleen system syndrome should be supplemented and spleen strengthened,while in heart system syndrome,blood circulation should be promoted and blood stasis removed.5.With the progress of diabetic nephropathy,symptoms such as spontaneous perspiration,cardiothoracic vexation and heat,impatience and irritability gradually decrease,and symptoms such as dark complexion and edema of face and feet gradually increase.6.Lung syndrome is correlated with white blood cells.With the increase of white blood cells,the incidence rate of lung syndrome is higher.7.Heart syndrome is correlated with serum total protein.The lower the total protein,the higher the incidence of heart syndrome.8.Kidney syndrome is correlated with age and 24-hour urine protein quantity.The older the age,the more 24-hour urine protein quantity,the higher the incidence rate of kidney syndrome.9.With the progression of diabetic nephropathy,there is no statistical significance in the change of the number of visceral diseases,but there is a gradual increase in the number of two visceral diseases and four visceral diseases.