| Objective: To observe the clinical effect of Professor Zhang Xuexin on patients with coronary heart disease and angina pectoris,and to collect case data;By using the software "TCM inheritance assistance platform V2.5",the case data was analyzed and mined,and the results of patient age,syndrome type,prescription used,medication and prescription composition were obtained.The obtained data was discussed,the rules and ideas of Professor Zhang Xuexin’s application of classical prescriptions were explored,and his academic thoughts and experience in the treatment of such diseases were summarized.To provide more reference for clinical treatment work.Methods: From October 2020 to September 2022,200 patients with coronary heart disease and angina pectoris in the outpatient department of Professor Zhang Xuexin,Department of Cardiovascular Disease,Qinhuangdao Hospital of Traditional Chinese Medicine were selected.The case data were recorded and observed for 4 weeks.After the observation period,the efficacy of Western medicine symptoms and traditional Chinese medicine symptoms were evaluated.Input the data obtained from the above process into the software of "TCM Inheritance Assistance Platform V2.5",establish the sample database,and analyze all the data.The analysis methods include frequency statistics,prescription law statistics,cluster analysis,etc.,and make statistical tables,statistical charts and network charts.To explore the results,explore Professor Zhang Xuexin’s syndrome differentiation and prescription medication rules in the treatment of such diseases,and learn his academic thought and clinical experience.Results: After 4 weeks of treatment for 200 patients,the effective rate of Western medicine symptoms was 92%,and the effective rate of Chinese medicine symptoms was 90.5%.Patients aged 60 and above accounted for61.5% of the total sample size,and the gender composition was more female than male.In addition to the main symptoms of "chest pain,chest tightness",18 kinds of symptoms such as shortness of breath,fatigue,irritability,loose stool appear frequently.There were 13 types of syndrome:deficiency of heart and spleen,syndrome of liver depression and spleen deficiency,syndrome of phlegm-heat internalization,syndrome of liver depression and fire,syndrome of spleen deficiency and dampness,syndrome of spleen and kidney Yang deficiency,syndrome of Xinyang depression,syndrome of Shaoyang disease,syndrome of qi stagnation and blood stasis,syndrome of Yin deficiency and fire growth,syndrome of Qi and Yin deficiency,syndrome of spittoon and qi obstruction,and syndrome of cold coagulation of meridians.A total of 13 treatment methods were applied: tonifying the heart and spleen,soothing the liver and strengthening the spleen,clearing heat and reducing phlegm,soothing the liver and reducing fire,strengthening the spleen and dampness,warming the spleen and kidney,warming the heart and Yang,reconciling Shaoyang,activating blood and Qi,nourishing Yin and reducing fire,invigorating the Yin,regulating qi and reducing phlegm,warming the meridian and dispelling cold.There are a total of 11 prescriptions used: Guipi Decoction,Xiaoyao powder,Sini powder,Wendan decoction,Dan Zhi Xiaoyao powder,Buzhong Yiqi decoction,Shenling Baizhu powder,Linggui Shu Gan decoction,Xiaobupleurum plus keel oyster soup,Gualou Allium Baigui Zhi soup,Huanglian Wendan soup.Analysis of drug frequency: A total of 169 kinds of drugs were used by the tutor in the samples,and the top 10 most frequently used Chinese herbs were: Xylobalm,licorice,bupleurum bupleurum,stir-fried atractylosum,poria codonicus,ligusticum Chuanxiong,Astragalus membranaceus,codonopsis codonopsis and scutellaria baicalensis.According to the application frequency,there are 11 kinds of Chinese medicines,which are tonifying deficiency,regulating qi,clearing heat,calming the mind,relieving surface,promoting blood circulation and removing blood stasis,regulating water and expelling dampness,reducing phlegm and cough and antiasthmatic,removing dampness,warming Li and relieving food.Statistics of the four Qi and five flavors of drugs: Among the 169 traditional Chinese medicines used by the tutor,the three kinds of drug properties of the four qi were the most common,which accounted for 95.73% of the total samples.Among the five tastes,sweet,bitter and octyl were the most,accounting for 92.28% of the total samples.Drug channel normalization statistics: Among all drugs,spleen,heart,liver,kidney and lung channels were the most common,accounting for 74.71% of the total sample.Analysis of prescription rule:According to the frequency analysis of drug combinations,23 groups of drug combinations with high frequency such as "Xylem + Xiangfu" were obtained,as well as 12 prescription rules,and 3 groups of new prescriptions were obtained by cluster analysis.Research conclusion: The syndrome differentiation of chest Bi and heart pain in the clinical treatment of coronary heart disease and angina pectoris mainly consisted of the syndrome of heart and spleen deficiency,liver depression and spleen deficiency,phlegm-heat intrinsic syndrome,liver depression and fire transformation,spleen deficiency and dampness and spleen and kidney Yang deficiency,accounting for 83.5%.The remaining syndrome was heart-yang depression,Shaoyang disease,qi stagnation and blood stasis,Yin deficiency and fire growth,qi and Yin deficiency,resistance of spittoon and qi to coagulative meridians,accounting for 16.5%.The prescription used to Guipi decoction,Xiaoyao powder,Sini powder,Wendan decoction,Dan Zhi Xiaoyao powder 11 first prescription more,accounting for 96% of the total.There were 169 kinds of traditional Chinese medicines used,among which the three kinds of medicines were warm,cold and peaceful,the three kinds of medicines were sweet,bitter and xin,and the main ones were spleen,heart,liver and kidney. |
