| Objective: To explore the relationship between healthy sleep score and urolithiasis risk in adults.Method: Using the UK Biobank(UKB)database,people recruited to UKB from 2006 to 2010 were selected as research objects,five dimensions of healthy sleep at baseline including early chronotype,sleep 7–8 h/d,free of insomnia,no snoring,and no frequent excessive daytime sleepiness were used to generate a healthy sleep score.Cox regression was used to analyze the relationship between healthy sleep score and the risk of urolithiasisResults:1.After controlling for covariates,healthy sleep scores were negatively associated with the risk of urolithiasis.The healthy sleep score was used as a continuous variable,and the risk of urolithiasis was reduced by 7% for every one-point increase in the score.2.Further analysis of the correlation between the components of healthy sleep score and the risk of urolithiasis showed that:(1)The risk of urolithiasis in the early chronotype group was 3% lower than that in the non-early chronotype group(HR 0.97,95% CI:0.91-1.03),with no statistically significant difference between the two groups(P =0.300).(2)The risk of urolithiasis was 4% lower in the no frequent daytime sleeping group than in its control group(HR 0.96,95% CI:0.90-1.03),with no statistically significant difference between the two groups(P =0.270).(3)Insomnia is a risk factor for urolithiasis.After adjusting for covariates,the risk of urolithiasis was 7% lower in the free of insomnia group than in the insomnia group(HR 0.93,95% CI:0.86-0.99,P =0.034).(4)Snoring is a risk factor for urolithiasis.the no snoring group had a 7%lower risk of urolithiasis than the snoring group(HR 0.93,95%CI :0.86-0.99,P=0.034).(5)Sleep duration was a protective factor for urolithiasis: After adjusting for multiple factors,the risk of urolithiasis was 12% lower in those who sleep 7-8 h daily(HR 0.88,95% CI:0.83-0.94,P <0.001).3.After removing the relevant interfering factors and treating the missing values of the data by interpolation method,the healthy sleep score still showed a negative correlation with the risk of urolithiasis,that is,with the increase of healthy sleep score,the risk of urolithiasis gradually decreased.After controlling for many factors,healthy sleep scores were negatively associated with the risk of urolithiasis.4.Subgroup analysis found that:(1)The risk of urolithiasis decreased significantly in the male group with an increase in healthy sleep score compared to the 0-1 group(P <0.05),and there was no significant difference in the female group(P >0.05)(2)The risk of urolithiasis decreased significantly as healthy sleep scores increased in those who were age under 60,non-smoking,moderately active and underweight,and had no history of hypertension or diabetes(P <0.05).(3)In the healthy diet group,healthy sleep score was not significantly associated with the risk of urolithiasis,while in the non-healthy diet group,the risk of urolithiasis decreased significantly with the increase of healthy sleep score(P <0.05).Conclusions:(1)Healthy sleep scores were inversely associated with urolithiasis risk(2)Individuals who slept 7 to 8 hours a day without insomnia or snoring had a significantly lower risk of urolithiasis.(3)Healthy sleep is significant for reducing the risk of urolithiasis in male,younger people and those with unhealthy diets.(4)Healthy sleep and no smoking,moderate exercise,low body weight,no history of hypertension and diabetes have significant synergistic effect on the risk of urolithiasis. |
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