Analysis Of Risk Factors Of White Matter Ischemic Lesions And Its Correlation With The Intracranial Atherosclerosis

Background and Purpose : white matter Ischemic lesions(WMIL)specifically refer to white matter lesions caused by vascular factors and are the most common type of white matter lesions in clinical practice.white matter Ischemic lesions is one of the types of cerebrovascular small vessel disease(CVSD).The onset of this disease is hidden.At present,the incidence rate of this disease in the elderly population is increasing year by year.Many studies have shown that white matter Ischemic lesions is related to the incidence rate,prognosis and rehabilitation of cerebral infarction and cerebral hemorrhage,and also affects gait,mood and quality of life.However,the risk factors for white matter Ischemic lesions are not yet very clear,and it is widely believed that ischemic white matter lesions are a pathological change caused by multiple factors.At different age stages,risk factors may vary,and white matter Ischemic lesions may vary in different regions.Therefore,studying the relationship between them can help us better understand white matter Ischemic lesions and provide new ideas for prevention and treatment.Objective: To explore the risk factors of white matter Ischemic lesions,and analyze the relationship between white matter Ischemic lesions and its severity with intracranial atherosclerosis in different age stages.To analyze the relationship between white matter Ischemic lesions in different parts of the brain and the severity of intracranial atherosclerosis.Methods Collect relevant clinical data of 225 patients with cerebrovascular diseases who were hospitalized in the Neurology Department of the Second Affiliated Hospital of Guangzhou Medical University from September 2021 to February 2023,and collect basic clinical data of all patients.All patients need to collect basic clinical data,conduct blood sampling tests,and other relevant examinations to complete cranial magnetic resonance imaging.The Fazekas scale was used to score the white matter lesions of patients,and they were divided into two groups: the non white matter ischemic lesions group and the ischemic white matter lesions group.The baseline data of both groups were analyzed,including 3 qualitative data,Chi-square test,and 8 quantitative data.Independent sample t-test was used to compare the baseline data and the risk of disease of all enrolled patients using a binary logistic regression analysis.A further 169 patients in the case group were divided into mild,moderate,and severe white matter lesions according to the Fazekas scale scoring criteria.Then analyze the baseline data of three groups of patients,conduct a single factor logistic analysis of statistically significant indicators,and finally conduct a multiple factor logistic analysis.Divide the two groups of patients into two groups based on their age of 65 years,and identify the risk factors for WMIL in patients over 65 years of age and under 65 years of age according to the above methods.Finally,all patients were divided into mild,moderate and severe groups according to the severity of intracranial atherosclerosis,and the Fazekas scale scores between the three groups were compared for statistical differences.Results 1.Multivariate logistic analysis showed that hypertension [OR=5.075,P<0.001],degree of intracranial atherosclerosis [moderate: OR=4.050,P=0.038,severe: OR=4.097,P=0.043] had statistical significance.2.Multivariate logistic analysis showed that the risk factors for the severity of WMIL were hypertension(OR=2.382,P=0.009)and the severity of intracranial atherosclerosis(moderate: OR=3.695,P<0.001,severe: OR=4.158,P<0.001)with statistical significance.3.After age grouping,hypertension(OR=5.052,P=0.007)was statistically significant in the population under 65 years old through multivariate logistic analysis.4.After age grouping,hypertension [OR=5.373,95% CI(1.549-18.638),P=0.008],diabetes [OR=10.947,95% CI(0.852-0.994),P=0.035],and hypersensitive C-reactive protein [OR=1.710,95% CI(1.020-2.876),P=0.042] have statistical significance in people over 65 years old.5.The severity of para lateral ventricle WMIL and subcortical WMIL increased with the severity of intracranial atherosclerosis,and the difference was statistically significant(P<0.05).Conclusions 1.Hypertension and intracranial atherosclerosis are independent risk factors for white matter Ischemic lesions,and they are also independent risk factors affecting the severity of white matter Ischemic lesions.2.After age grouping,hypertension may be an independent risk factor for the development of WMIL in people under 65 years old.3.After age grouping,hypertension,diabetes,and high-sensitivity C-reactive protein may be independent risk factors for WMIL.4.The degree of intracranial atherosclerosis was positively correlated with the severity of para lateral ventricle WMIL and subcortical WMIL.