The Associated Study Between Cystatin C And White Matter Lesions

ObjectiveExplore the relationship between the level of Cystatin C and white matter lesions,as well as discussing the level of CYSC in different degrees of white matter lesions.The level of CYSC was also analyzed in patients, who had cerebral white matter lesions, with or without acute ischemic stroke to explore whether CYSC could be a predictor for acute ischemic stroke in patients with cerebral white matter lesions.MethodsThe clinical data were studied between 426 patients with cerebral white matter lesions and 402 normal control to estimate the risks of cerebral white matter lesions.The two groups were also analyzed by single factor and multiple variables logistic regression, the receiver operating characteristic curve(ROC curve) were also generated. Through the head MRI, Fazekas grading of cerebral white matter lesions were evaluated, then it was easy for us to know the relationship between CYSC levels the different degree of cerebral white matter lesions. CYSC was also tested in patients,who had cerebral white matter lesions, with acute ischemic stroke(N=75 cases) and without ischemic stroke(N=107), which could help to know whether the level of CYSC in patients with cerebral white matter lesions a predictor for acute ischemic stroke.Results1. There were significant difference between normal control and patients with cerebral white matter lesions in hypertension, glycosylated hemoglobin, renal function, plasma homocysteine and Cystatin C(P<0.05), which indicated that they were realted to the occurrence of cerebral white matter lesions.2. Through the results of single factor Logistic regression of LnCYSC, there were significant difference between cerebral white matter lesions and normal control. After the adjustment for risk factors, P value was still less than 0.01, which suggested that CYSC might be an independent risk factor for cerebral white matter lesions.3. The cerebral white matter lesions were classified by image, CYSC level were raised with the increased scores in white matter lesions.4. Compared with patients without acute ischemic stroke in cerebral white matter lesions with those with acute ischemic stroke, CYSC levels were significantly increased(P<0.05). After multivariate calibration, the difference was statistically significant(P<0.05) too, which suggested that CYSC might be an independent risk factor for ischemic stroke.ConclusionCYSC was an independent risk factor for cerebral white matter lesions, and was significantly correlated with progression of cerebral white matter lesions. It could also predict the occurrence of acute ischemic stroke in patients wiht cerebral white matter lesions.