| ObjectiveTo investigate the epidemiological characteristics,risk factors and cognition of HPV infection among women with and without household registration in Guangming District of Shenzhen city,and to provide effective scientific theoretical basis for cervical cancer prevention and treatment among different population in this area.Methods1、The Cobas? 4800 HPV test was performed on 2659 non-registered and 596 registered women in Guangming District of Shenzhen city.Total detection of HPV16,18 and other 12 species(31,33,35,39,45,51,52,56,58,59,66 and 68)were detected by Cobas? 4800 HPV test.The risk factors of infection and their knowledge of HPV were investigated by questionnaire.2、Statistical methods SPSS 22 statistical software was used for statistical analysis.Chi-square test was used for comparison of counting data,and P<0.05 was considered statistically significant.Multivariate analysis Multivariate non-conditional Logistic regression analysis was used to screen out the associated independent risk factors for high-risk HPV infection and calculate the risk odds ratio(OR value).Results1、3255 women were enrolled in the study.404 high-risk HPV-positive patients were detected,with an overall infection rate of 12.41%.Among the different age groups,the highest rate was 13.80% in the 18～29 age group.Among 2659 women in the non-registered population group,346(13.01%)were found to be HPV positive,including 128HPV16,71HPV18 and 147 other 12 high-risk HPV,accounting for78.03%.Mixed infections accounted for 21.97%.Among the 596 women in the household registration group,58 were positive for high-risk HPV,with a positive rate of 9.73%.Among them,17 were HPV16,16 were HPV18,and 25 were other 12high-risk HPVs.single high-risk infection accounted for 82.76%.Mixed infection accounted for 17.24%.The infection rate of the two groups was statistically significant,and the infection rate of the non-registered group was significantly higher than that of the registered group(13.01% VS 9.73%).2、 Multivariate non-conditional Logistic regression analysis showed that the age of first sexual intercourse <18 years old,number of sexual partners≥3,extramarital sexual behavior of husbands,low education level,low economic income level and recurrent vaginitis were independent risk factors for high-risk HPV infection in non-registered women.The risk factors included age of first sexual intercourse <18years,number of sexual partners≥3,extramarital sex of the husband,and repeated vaginitis,and HPV vaccination was a protective factor.3、Through the questionnaire survey and related data analysis results,we learned that 90.23% of the respondents had heard of HPV,only 28.29% knew that high-risk HPV infection can cause cervical lesions,and 18.77% of the respondents believed that early sexual behavior is a high risk factor for HPV infection.Only 13.64% knew HPV test,20.28% knew HPV can be transmitted sexually,and 24.76% knew HPV vaccine.32.50% of the knowledge about HPV came from friends and relatives,42.09% from the Internet,14.99% from TV,4.79% from magazines,and 5.59% from other sources.The HPV awareness rate in the registered group was significantly higher than that in the non-registered group(93.12% VS 87.36%),and the difference was statistically significant(P<0.05).The HPV vaccine awareness rate in the registered group was significantly higher than that in the non-registered group(26.68% VS 22.79%),and the difference was statistically significant(P<0.05).There was no significant difference in HPV vaccination willingness rate between registered and non-registered women(90.11% VS 89.77%)(P>0.05).Conclusion1、Compared with the registered population,the infection rate of high-risk HPV in non-registered women in Guangming area of Shenzhen is significantly higher,and single infection is dominant in both registered and non-registered women.2、Age of first sexual intercourse,number of sexual partners,extramarital sex of husbands,and recurrent vaginitis were common factors for high-risk HPV infection in both registered and non-registered women.In addition,education level and income level were independent risk factors for high-risk HPV infection in non-registered women,and HPV vaccination was a protective factor for registered women.3、The infection rate of different age groups in Guangming District of Shenzhen was different,with the highest infection rate in 18～29 years old group and the lowest infection rate in 30～39 years old group.There were significant differences between the two groups.The infection curve of each age group showed U-shaped distribution.4、In terms of HPV cognition survey,the HPV awareness rate and vaccine awareness rate of registered women are higher than those of non-registered women.Surveys show that the Internet is becoming the main source of HPV knowledge. |
PDF Full Text Request