The Association Between Serum Uric Acid And Atherosclerotic Carotid Artery

Objective Cervical arteriosclerosis stenosis was one of the important causes of ischemic stroke.The high rate of disability and death caused by stroke brings heavy burden to both individual and family.Therefore,it was very important to identify and prevent the regulative factors of cervical arteriosclerosis stenosis.To investigate the relationship between serum uric acid and cervical arteriosclerosis stenosis in both acute stroke and non-stroke arteriosclerosis,and to effectively assess the occurrence of cervical stenosis in stroke and non-stroke patients,to provide reasonable and accurate forecasting methods,and timely prevention.Methods The research subjects were acute ischemic stroke patients hospitalized in the Department of Neurology at Linyi People’s Hospital from January to December 2021,as well as some individuals who underwent comprehensive health screening at the physical fitness center during the same period.Patients with acute ischemic stroke(within 7 days after onset)was diagnosed according to the clinical criteria for ischemic stroke or confirmed by magnetic resonance imaging(MRI),among them,584 cases of acute ischemic stroke were selected as case group,and 319 cases of non-stroke group matched in sex and age were selected as control group.The uric acid level was measured by uricase-Peroxidase method.Neuroimaging including Magnetic resonance scanning MRI was performed to assess acute ischemic stroke,and ultrasound of the cervical vessels was performed,to determine if there was a Carotid artery stenosis.We defined Carotid artery stenosis ≥50% or occlusion as arteriosclerosis stenosis.Continuous variables conforming to a normal distribution were described with mean ± standard deviation and those not conforming to a normal distribution were described with median(interquartile range);analysis of variance or rank sum test was used for comparison between groups.Categorical variables were expressed as percentages,and the chi-square test was used when categorical variables were compared between groups.Multivariate Logistic regression models were used to assess the association between serum uric acid and Carotid artery stenosis.SPSS23.0was used to analyze the data of all participants,P < 0.05 was statistically significant.Results We included 584 patients with acute ischemic stroke(168 Carotid artery stenosis and 416 Carotid artery stenosis)and 319 non-stroke patients(70 Carotid artery stenosis and 249 Carotid artery stenosis).Of these,uric acid levels were lower in the non-stroke group than in the stroke group(282 in the non-stroke Group and 295 in the stroke group,P = 0.009).In univariate analysis,risk factors for Carotid artery stenosis included age,sex,uric acid,hypertension,coronary heart disease,diabetes and smoking.After adjusting for risk factors,multivariate Logistic regression analysis showed that uric acid level in the general population(OR 1.250,95% CI 1.069-1.460p= 0.005)was associated with Carotid artery stenosis risk,in the ischemic stroke group(OR 1.27795% CI 1.055-1.546 p = 0.012).Non-stroke group(OR 1.361,95% CI1.018-1.818 p = 0.037).The receiver operating characteristic curve(ROC curve)showed that the optimal cut-off value for predicting patient Carotid artery stenosis was 269.5 umol/L(area under the curve(AUC)value 0.586,95% CI = 0.544-0.628,p< 0.001),and the sensitivity was 71.4%,the specificity was 54.1%.Conclusion The experimental study shows that serum uric acid was an independent factor in the occurrence of carotid atherosclerotic stenosis in all participants.Elevated serum uric acid levels have a certain predictive effect on the risk of carotid artery stenosis.At the same time,age,sex and diabetes were also risk factors for carotid atherosclerosis stenosis in all participants,and were not related to stroke.