Functional Magnetic Resonance Imaging Study Of Vestibular Migraine And Benign Paroxysmal Positional Vertigo

Objective By processing and analyzing the resting f MRI images of patients with interictal vestibular migraine and patients with benign paroxysmal positional vertigo,we can obtain the spontaneous neuronal activity and brain functional network connection of their respective brain regions,so as to further explore the pathogenesis of vestibular migraine.Methods three groups of subjects matched with general data(such as gender,age and education level)were scanned by resting f MRI.The three groups of subjects were 21 patients with vestibular migraine(VM),20 patients with benign paroxysmal positional vertigo(BPPV)and 19 healthy people.Firstly,MRIconvert software is used to convert the data format from DICOM to nifti format that can be recognized by data processing workstation,and then mricron software and spm12 based on MATLAB are used to check the image quality.Then the original image is processed by restplus software,and the analysis of variance is carried out by spm12.The statistical method of Bonferroni multiple comparison is used to obtain the brain regions with differences in local consistency(Re Ho)and low frequency amplitude(Alff),and the Alff is corrected by GRF.Then the brain regions with the most significant differences in Re Ho and Alff were analyzed and compared by functional connectivity(FC).Results(1)Alff comparison: compared with healthy people,the Alff value of left hippocampus in BPPV patients was significantly higher(P < 0.05),but there was no significant difference in VM patients;The Alff value of left hippocampus in BPPV patients was significantly higher than that in VM patients(P < 0.05).(2)Re Ho comparison: compared with healthy people,the Re Ho value of the right middle frontal lobe in patients with VM was significantly higher(P < 0.05),and the Re Ho value of the right middle frontal lobe in patients with BPPV was significantly lower(P < 0.05);Compared between the two groups,the Re Ho value of the right middle frontal lobe in VM patients was significantly higher than that in BPPV patients.(3)The left hippocampus of the three groups with the most significant difference in Alff was the area of interest.Compared with healthy people,the functional connection between thalamus and seed point in VM patients and BPPV patients was enhanced(P < 0.05);The functional connectivity of thalamic area in BPPV patients was more significantly enhanced than that in VM patients(P < 0.05).(4)Compared with healthy people,the functional connection between the right prefrontal lobe and seed point in patients with VM was significantly enhanced(P < 0.05),and the functional connection between the right prefrontal lobe and seed point in patients with BPPV was significantly reduced(P <0.05);The functional connectivity of the right prefrontal lobe in patients with VM was stronger than that in patients with BPPV(P < 0.05).Conclusion there are significant differences in the analysis of brain functional magnetic resonance data between patients with vestibular migraine and benign paroxysmal positional vertigo,which can explain that vestibular migraine is different from benign paroxysmal positional vertigo,and indirectly explain that vestibular migraine belongs to the theory of central nervous system disease,which is helpful to better understand the pathogenesis of vestibular migraine.