Clinical Analysis Of Blood Indicators In Patients With Pre-eclampsia

Objective:To analyse the changes and clinical significance of blood parameters in patients with varying degrees of pre-eclampsia(PE).Methods:We carried out a retrospective research to gather clinical information about PE patients admitted to the First Hospital of Shanxi Medical University.To compare the variations in blood indices between each group,67 patients from the group with PE and 81 patients from the group with severe PE were chosen as the observation group and 177 normal pregnant women from the same time were chosen at random as the control group.Results:1.Indicators related to blood routine:Leukocyte count,neutrophil count,platelet distribution width(PDW),mean platelet volume(MPV),erythrocyte count,red blood cell volume distribution width(RDW),neutrophil to lymphocyte ratio(NLR)and hematocrit(HCT)were all greater than they were in the control group in the observation group(P<0.05).The serious PE group had higher neutrophil counts,leukocyte counts,MPV,erythrocyte counts,RDW and NLR values than the PE group(P<0.05).Both the group with serious PE and the PE group had lower hemoglobin levels than the control group,and the serious PE group had lesser Hb level than the PE group(P<0.05).2.Indicators related to coagulation function:The levels of activated partial thromboplastin time(APTT),prothrombin time(PT)and antithrombin Ⅲ(AT-Ⅲ)were lower in the observation group than those in the control group.The levels of APTT,PT and AT-Ⅲ in the severe PE group were also lower than those in the PE group(P<0.05).The fibrinogen content in the observation group increased when compared to the control group(P<0.05).3.Related indicators of liver and kidney function:The observation group had higher alanine aminotransferase(ALT),aspartate amino aminotransferase(AST),creatinine(CRE),uric acid(UA)and blood urea nitrogen(BUN)values when compared to the control group.The ALT,AST,CRE,UA and BUN levels in the group with severe PE were greater than those in the PE group(P<0.05).The levels of total protein(TP)and albumin protein(ALB)fell in the observation group,and the levels of TP and ALB in the severe PE group were lower than those in the PE group(P<0.05).Conclusion:In clinical work,there is a lack of breakthrough in early diagnosis and disease assessment of PE,and the existing prediction methods lack accuracy and are difficult to implement.Blood routine,blood coagulation function and liver and renal function have important clinical significance for early diagnosis and disease assessment.