| Objective Through a randomized and controlled clinical study,observe and evaluate the diuretic effect of the Mongolian medicine Ganluyangxin pill on Jiruhenhabeng(chronic heart failure)disease and its influence on the rate of rehospitalization within 30 days,so as to provide a scientific basis for the new way of Mongolian medicine to treat CHF.Methods To selected the 103 inpatients in April 2021 to November 2022,diagnosed as Jiruhenhabeng disease in the Department of Cardiology of International Mongolian Medical Hospital of Inner Mongolia Autonomous Region and the Department of Cardiology of Wushenqi Mongolian Medical General Hospital were randomly divided into 35 cases in the Ganluyangxin pill group,34 cases in the Haijinsha-8 powder group and 34 cases in the Western medicine control group.Patients in the Western medicine control group were given conventional Western medicine treatment,and the Ganluyangxin pill group was given conventional Western medicine treatment plus Ganluyangxin pill 3g(15 pills)/ time,2times/day;the Haijinsha-8 powder group was given conventional western medicine treatment plus Haijinsha-8 powder 3g/time,2 times/day,and the treatment cycle of the three groups was42 days.The test data were obtained by observing the rehospitalization rate of 30 days,24-hour urine volume,NT-Pro BNP,left ventricular ejection fraction(LVEF),NYHA classification grading of cardiac function,Mongolian medical syndrome scores,6-minute walking distance(6MWD),Minnesota living with heart failure questionnaire(MLHFQ),blood routine,urine routine,liver and kidney function,and electrolytes in the three groups of patients,and the statistical software SPSS25.0 was used to statistically analyze the test data and evaluate the efficacy and safety.Results 1.Before treatment,there were not statistically significant in gender,age,comorbid disease,NT-Pro BNP,left ventricular ejection fraction(LVEF),NYHA classification grading of cardiac function grade,Mongolian medical syndrome scores and six-minute walk test,Minnesota living with heart failure questionnaire(MLHFQ),urine volume among the three groups of patients.2.Comparison of rehospitalization rates within 30 days after treatment: the total effective rate of the Ganluyangxin pill group reached 93.33%;the total effective rate of Haijinsha-8 powder group was 76.67%;the total effective rate of the Western medicine control group was 76.67%,and the difference were statistically significant(P<0.05).3.Comparison of 24-hour urine volume in the three groups : the average 24-hour urine volume values on the 7th,14 th,21st,28 th,and35th days of diuretic treatment increased to varying degrees,and the differences were statistically significant compared with the first day of treatment(P<0.05).The average24-hour urine volume of the three groups on the 7th,14 th,21st,28 th,and 35 th days after treatment was statistically significant(P<0.05).On the 42 nd day of treatment,the average24-hour urine output of patients in the Ganluyangxin pill group was 1368.33±109.70 ml,the average 24-hour urine output of patients in the Haijinsha-8 powder group was 1168.83±83ml,and the average 24-hour urine output of patients in the Western medicine control group was1128.33±104.62 ml,all of which were statistically significant(P<0.05).It was suggested that all three groups had diuretic effects,and the diuretic effect of the Ganluyangxin pill group was better than that of Haijinsha-8 powder group and Western medicine control group.4.Comparison of NT-pro BNP values between the three groups: the decrease in NT-pro BNP values in the Ganluyangxin pill group was statistically significant(P<0.05),but the decrease in NT-pro BNP values in Haijinsha-8 powder group and Western medicine control group was not statistically significant compared with before treatment(P>0.05).5.There was no significant difference in LVEF values between the three groups compared with before treatment(P>0.05).6.After treatment the quality of life score of Minnesota living with heart failure questionnaire(MLHFQ)was significantly compared within the three groups,the average points of the Ganluyangxin pill group was 45.10±4.38,the average points of the Haijinsha-8 powder group was 54.03±4.52,and the average points of the Western medicine control group was 56.60±2.98,the difference were statistically significant(P<0.05).7.Compared with the 6-minute walking distance(6MWD)after treatment: the average distance of the Ganluyangxin pill group was 431.60±79.64 m,the average distance of the Haijinsha-8powder group was 389.53±85.73 m,and the average distance of the Western medicine control group was 370.77±84.21 m,the difference were statistically significant(P<0.05).8.Compared with the total clinical efficacy of Mongolian medical syndrome: after treatment in the three groups,the total effective rate of Ganluyangxin pill group was 93.3%,the total effective rate of Haijinsha-8 powder group was 50.0%,and the total effective rate of Western medicine control group was 56.6%,the difference were statistically significant(P<0.05).The points of various Mongolian medical symptoms : after treatment the symptoms of dyspnea,edema and chest tightness were statistically significant(P<0.05),and the Ganluyangxin pill group was better than the other two groups.However,there was no significant difference in the fatigue symptoms between the three groups(P>0.05).9.Compared with the improvement of NYHA heart function after treatment in the three groups,the total effective rate of Ganluyangxin pill group was 86.7%,the total effective rate of Haijinsha-8 powder group was 56.7%,and the total effective rate of Western medicine control group was 50.0%,and the difference were statistically significant(P <0.05).10.After treatment,there were no significant differences in blood routine,urine routine,liver function and kidney function before and after treatment between the three groups(P>0.05).There were no significant differences in the comparison of electrolytes in the Ganluyangxin pill group(P>0.05).There were significant differences in serum potassium and magnesium in the Haijinsha-8 powder group(P<0.05).There was significant difference in serum magnesium in the Western medicine control group(P<0.05).Conclusion 1.Mongolian diuretics medicine Ganluyangxin pill combined with western medicine for CHF treatment can reduce the rehospitalization rate of patients within 30 days.2.Mongolian diuretics medicine Ganluyangxin pill has great diuretic effect,and the diuretic effect is stronger than the Mongolian diuretic medicine Haijinsha-8 powder;Ganluyangxin pill combined with western medicine in the treatment of CHF can significantly increase the urine output of patients.3.Mongolian diuretics medicine Ganluyangxin pill combined with western medicine in the treatment of CHF has a significant effect,which can significantly reduce the level of NT-pro BNP,improve heart failure symptoms and heart function,and significantly improve quality of life and exercise tolerance.4.Ganluyangxin pill has fewer adverse reactions and toxic side effects,has better safety and great clinical value,it is worthy of promotion and application in CHF. |
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