Effect Of Laparoscopic Sleeve Gastrectomy On Epicardial Fat Thickness In Obese Patients

Objectives:To investigate the therapeutic effect of laparoscopic sleeve gastrectomy LSG on improving epicardial adipose tissue EAT thickness in patients with obesity.Methods:The clinical data of 34 obese patients who underwent LSG in general surgery from June 2021 to December 2022 were randomly adopted at the Affiliated Hospital of Yunnan University and followed up continuously for 12 months after surgery,including the presence of postoperative complications and related adverse reactions,and the preoperative and 6 and 12 months postoperative test indicators,clinical data and imaging examinations were recorded:1.Patient human indicators.Body Mass index（BMI）,percentage of excess weight loss（EWL%）,height,age,weight;2.Glycosylated hemoglobin Hb A1c).3.total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein（HDL-C）,low-density lipoprotein（LDL-C）.4.Blood pressure:systolic blood pressure（SBP）Systolic blood pressure（SBP）.5.Abdominal visceral fat（AVF）was measured using bioresistive electrical methods and epicardial adipose tissue（EAT）thickness was measured using cardiac MRI.Various clinical parameters were analysed before and after surgery to compare the changes in epicardial fat thickness in obese patients by LSG.The SPSS 26.0 software was used for statistical analysis of the preoperative and postoperative time periods.P<0.05 was used to determine the statistical significance of the differences in the relevant variables.Results:All 34 patients included in this study completed the surgery successfully,and there were no deaths in any of the patients.There were no intraoperative anaesthetic accidents,no intraoperative openings or intraoperative haemorrhage.At 6 and 12 months follow-up,the patients recovered well without postoperative incisional infections,malnutrition and vitamin deficiencies,anastomotic stenosis and anastomotic fistula,anastomotic bleeding or complications from other causes.Postoperative follow-up was successfully completed and relevant indicators such as weight,BMI,Hb A1c,TC,TG,LDL-C,SBP,AVF data were significantly lower than before surgery,with statistically significant differences（P<0.05）,and it was observed that Pre-operative HDL-C and EWL%were significantly higher compared to the pre-operative comparison.Pre-operative MRI showed that the mean thickness（mm）of EAT was（6.86±0.98）in 34 obese patients,which decreased to（6.01±0.91 and 5.45±0.89）at 6 and 12months,respectively（P<0.01）,which was divided into a 12.3%and 20.5%decrease compared to the pre-operative period.According to pearson correlation analysis,preoperative EAT correlated significantly with BMI and visceral fat,showing a positive correlation(r₁=0.246,P<0.05,r₂₌0.636,P<0.01),from which I can conclude that visceral fat was strongly correlated with preoperative EAT thickness,while BMI was waekly correlated.Conclusion:Laparoscopic sleeve gastrectomy is an effective and safe procedure for obese patients.It is an effective way to reduce body weight while improving dyslipidaemia and reducing abdominal visceral fat and endocardial fat in the body,and is a treatment modality to improve future cardiovascular disease risk and metabolic syndrome.