Analysis Of Differences In Clinical Features Of 1574 Hospitalized Children With Rotavirus And Norovirus Enteritis

Objective:To research the infection situation about rotavirus(RV)and norovirus(NV)in Kunming from 2019 to 2021,and to analyze the clinical features of hospitalized children with RV and NV enteritis,the severity of their condition and their impact on the body.Method:The EXCEL table was used to collect general data,clinical manifestations,and laboratory test results of hospitalized and laboratory confirmed children with RV or NV infection in Kunming Children’s Hospital from 2019 to 2021 for statistical analysis.Results:1.Prevalence of RV and NV in outpatient clinics:From 2019 to 2021,a total of 161987 cases were detected in RV and NV outpatient clinics,and 32753 cases were positive,with a total positive detection rate of20.22%.Among them,the detection rate of RV was 19.12%(24038/125720),and the detection rate of NV was 24.03%(8715/36267).The detection rate of NV was higher than that of RV(P<0.05).2.Incidence of RV and NV infection in hospitalized children2.1 Demographic characteristicsThere were 3699 children hospitalized with RV and NV positive,and a total of1574 patients met the inclusion criteria,including 1000 cases of RV,422 cases of NV,and 152 cases of mixed infection.There were 983 boys and 591 girls,with rate of male and female is 1.66 to 1.The age of onset of RV ranged from 3 days to 4 years and 5months,and that of NV ranged from 17 days to 14 years and 11 months.2.2 Distribution in different yearsRV and NV occurred in different years,From 2019 to 2021,hospitalized children with RV infection showed a downward trend,from 40.00%in 2019 to 31.40%in 2021.However,the number of hospitalized children with NV has increased year by year,from 27.25%in 2019 to 42.89%in 2021.2.3 Distribution in different seasonsRV and NV occur throughout the year,with the peak incidence of RV occurring in December,January,and March,and NV occurring from November to December.The incidence of both is relatively low from June to October.There was a significant difference in children with RV and NV infection in each month(P<0.05).2.4 Different age distributionThe RV and NV both occur in different age groups,with the peak age of onset concentrated in 1-2 years old.After 2 years old,the number of cases decreases.There was significant differences in children with RV and NV infection at different ages(X~2=63.985,P<0.001),The proportion of NV infection among children aged 1-2,3-4,and over 4 years was higher than that of RV infection.3.Comparison of clinical features of children with RV and NV infectionThe duration of diarrhea,vomiting and the times of diarrhea in 24 hours in children with single RV infection and mixed RV infection were longer than that in children with NV infection.the Vesikari scores of children with RV and mixed infection were higher than those of children with NV infection in the gastrointestinal tract(Vesikari≥11).The incidence of dehydration and acidosis caused by RV infection is the highest,followed by NV infection.RV is more likely to be complicated with myocardial damage,and NV is more likely to be complicated with central nervous system symptoms.4.Vesikari score and clinical features compared between newborns and children of other agesNeonates with positive RV and NV had the lowest gastrointestinal Vesikari score,and children aged 2-3 years had the highest gastrointestinal Vesikari score.The Vesikari score of newborns was significantly different from other age groups(P<0.05);There was no significant difference in the gastrointestinal Vesikari score between children aged 2 to 3 years and children of other age groups(P>0.05).The probability of dehydration,acidosis,and respiratory symptoms in newborns was lower than that non newborns(P<0.05).There was no significant difference in the incidence of liver damage,myocardial damage,and electrolyte disturbance between newborns with diarrhea and older children(P>0.05).5.Comparison of laboratory indexes between RV and NV infected childrenThe effects of RV and NV infection on PLT,AST,CK,CK-MB,BUN,and Scr were statistically significant(P<0.05),PLT,AST,CK,CK-MB,Scr of RV infection were higher than NV(P<0.05),and the BUN with NV infection was higher than RV(P<0.05).Conclusion:1.From 2019 to 2021,the incidence of NV was higher than that of RV.2.RV infection has more severe gastrointestinal symptoms,more likely to have vomiting,dehydration,acidosis,and myocardial damage;NV infection is more likely to be associated with central nervous system symptoms.3.The Vesikari score and gastrointestinal symptoms of the neonates with RV and NV infection were milder than those of the other age.4.The incidence of dehydration,acidosis and respiratory system infection in neonatal diarrhea was significantly lower than that in other age groups.