| ObjectiveDiabetic retinopathy is a common chronic microvascular complication of type 2diabetes,and inflammation plays a key role in its occurrence and development.In recent years,it has been found that monocyte to high-density lipoprotein cholesterol ratio(MHR)can be used as an emerging inflammatory indicator and is associated with a variety of chronic inflammatory diseases.The purpose of this study is to explore the correlation between MHR and type 2 diabetic retinopathy,and provide new ideas for the prevention and treatment of type 2 diabetic retinopathy.MethodsThis study included 218 patients with type 2 diabetes who were hospitalized in the endocrinology department of the First Affiliated Hospital of Dali University from October 2020 to October 2022.Patients were divided into two groups according to whether they were associated with diabetic retinopathy,including 118 patients in the diabetic retinopathy group(DR group,n=118)and non-diabetic retinopathy group(NDR,n=100).The DR group was divided into non-proliferative diabetic retinopathy group(NPDR group,n=67)and proliferative diabetic retinopathy group(PDR group,n=43)according to the degree of retinopathy.Background information of enrolled pathway were collected including patients’ general information and laboratory tested paraments.Statistical analysis was carried out by SPSS27.0.Results1.Diabetic retinopathy group diabetes course,systolic blood pressure,fasting blood glucose,fasting insulin,fasting C peptide,insulin resistance index,creatinine,urea nitrogen,white blood cells,neutrophil absolute value,monocyte absolute value,MHR,neutrophil to lymphocyte ratio(NLR)are higher than those in the group without retinopathy,and the incidence of diabetic retinopathy in men is higher than that in women,the difference is statistically significant(P<0.05).2.The course of diabetes and creatinine in the proliferative diabetic retinopathy group is higher than that of non-proliferative diabetic retinopathy group,the total bilirubin,direct bilirubin and indirect bilirubin are lower than the non-proliferative diabetic retinopathy group.The difference is statistically significant(P<0.05).3.Multivariate logistic regression analysis shows that the course of diabetes(OR=1.091),systolic pressure(OR=1.029),insulin resistance index(OR=3.436),and MHR(OR=1.541)are independent risk factors for the occurrence of type 2 diabetic retinopathy(P<0.05).4.According to the quartile spacing of the MHR value,the patients in the group are divided into three groups.The incidence of diabetic retinopathy in Q1 group,Q2 group and Q3 group is 33.3%,55.4% and 73.6% respectively.The difference between the three groups is statistically significant(P<0.05).5.Pearson correlation analysis results show: MHR and fasting insulin(r=0.153),fasting C peptide(r=0.213),creatinine(r=0.137),triglyceride(r=0.251),neutrophil absolute value(r=0.367),lymphocytes The absolute value(r=0.149),the absolute value of monocytes(r=0.849),insulin resistance index(r=0.162)are positively correlated(P<0.05)and negatively correlated with high-density lipoprotein cholesterol(r=-0.509)(P>0.05).6.The ROC curve is used to evaluate the predictive value of MHR and NLR for type 2 diabetic retinopathy.The results show that the area under the MHR curve is0.717(95% CI: 0.649-0.786),the sensitivity is 66.1%,and the specificity is 75%;the area under the NLR curve is 0.620(95% CI: 0.536-0.685),with a sensitivity of 55.9%and a specificity of 67%.Conclusions1.Diabetes course,systolic pressure,insulin resistance index and MHR are independent risk factors for the occurrence of type 2 diabetic retinopathy.2.MHR could be potentially used as an early predictor for the occurrence of type2 diabetic retinopathy to help the early screening of type 2 diabetic retinopathy. |
