Study On The Relationship Between IL-18 And Heart Failure With Preserved Ejection Fraction

Objective: Objective: To investigate the correlation between serum interleukin-18 level and heart failure with preserved ejection fraction patients.Methods: From September 2021 to September 2022,30 patients with ejection fraction retaining heart failure admitted to the Department of General Medicine of the Fifth Affiliated Hospital of Xinjiang Medical University were selected as a case group(HFp EF group).According to the New York Heart Association cardiac function grading standard,9 patients were classified as cardiac function grade I-II,and 21 patients as cardiac function grade III-IV,In addition,30 patients with normal cardiac function who were admitted to the hospital during the same period without cardiovascular underlying diseases were selected as the control group(NHF group).Results: 1.The level of IL-18 in HFp EF group(2.533±1.246ng/m L)was higher than that in NHF group(1.447±0.978 ng/m L),P<0.05;In HFp EF group,the level of IL-18 in cardiac function grades I to II(1.597± 0.997 ng/m L)was lower than that in cardiac function grades III to IV(2.934±1.136 ng/m L),P<0.05;In HFp EF group,the level of N-terminal pro B-type natriuretic peptide in cardiac function class Ⅰ-Ⅱ was lower than that in cardiac function class Ⅲ-Ⅳ(2054.50±2071.83 pg/m L),P<0.05;Correlation analysis showed that serum IL-18 levels in patients with HFp EF were positively correlated with cardiac function grading,left atrium,and NT-pro BNP(r=0.500、0.456、0.403,respectively,P<0.05);Using binary regression analysis,it was shown that high levels of serum IL-18 and low levels of Left ventricular ejection fraction(LVEF)would increase the risk of HFPEF.Conclusion: 1.Inflammatory factor IL-18 is positively correlated with LAD,NT-pro BNP,and cardiac function grading of HFp EF.2.High levels of serum IL-18 and low levels of Left ventricular ejection fraction would increase the risk of HFPEF.