Summary Of The Law Of Prescriptions And Medicines Used By Professor Zhao DongKai In The Treatment Of Acute Exacerbation Of Chronic Bronchitis

Objective:Based on the clinical practice of treating chronic bronchitis in the Department of Pulmonary Disease of the Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine for many years,and using data mining technology as a means,this paper summarizes the prescription and medication patterns of Professor Zhao Dongkai in treating acute exacerbations of chronic bronchitis,providing new ideas for clinical treatment.Methods:From June 2020 to May 2022,a total of 342 cases of chronic bronchitis treated in outpatient and treatment areas during the acute attack period were collected and entered into the ancient and modern medical record cloud platform system.Statistical analysis,cluster analysis,association analysis,and complex network analysis were used to mine and analyze the data.Results:1.Professor Zhao Dongkai mainly treats middle-aged and elderly patients with acute exacerbation of chronic bronchitis,with more males than females,with a male to female ratio of 1.15:1.2.There are 5 types of TCM syndromes,with the frequency ranking from high to low:phlegm turbidity obstructing the lung,cold drink obstructing the lung,phlegm heat stagnating the lung,wind cold invading the lung,and wind heat invading the lung.3.According to statistics of traditional Chinese medicine,342 prescriptions shared 137 herbs,with a total frequency of 4572.The 10 herbs with the highest frequency were Pinellia ternate,Glycyrrhiza uralensis,Poria cocos,Magnolia officinalis,Perilla frutescens,Scutellaria baicalensis,dried ginger,cicada slough,white peony,and tangerine peel.4.The statistical results of the attributes of traditional Chinese medicine show that the four Qi medicines are mainly warm drugs,followed by cold drugs and mild drugs,while the five flavors are mainly pungent drugs,followed by sweet drugs and bitter drugs.The meridian tropism is mainly the lung meridian,followed by the spleen meridian and stomach meridian,with the main efficacy of eliminating dampness and phlegm,followed by heat clearing and detoxification,and reducing nausea and vomiting.5.Through cluster analysis,using Euclidean distance and class average method,five drug groups were obtained:(1)licorice,cicada slough,magnolia officinalis,purple perilla,pinellia ternata,and tuckahoe;(2): White peony,cinnamon twig,ephedra,dried ginger,schisandra chinensis,asarum;(3): Scutellaria baicalensis,Codonopsis pilosula,Chaihu,ginger,jujube.(4): Cynanchum paniculatum,Platycodon grandiflorum,Trichosanthin,tangerine peel,Fritillaria thunbergii,Trichosanthes trichosanthes;(5): Bitter almonds,gypsum,Fangfeng,Fructus Aurantii,Zhuru,Artemisia annua,and Folium Isatidis.6.The results of drug syndrome correlation analysis showed that Pinellia ternate,Magnolia officinalis,Poria cocos,liquorice,perilla seed,etc.were commonly used in the syndrome of phlegm obstructing the lung;"The syndrome of cold drinking and lung depression is commonly characterized by licorice,asarum,dried ginger,pinellia ternata,and schisandra chinensis.";"The syndrome of phlegm heat stagnation in the lung is commonly characterized by scutellaria baicalensis,pinellia ternate,tuckahoe,tangerine peel,and artemisia annua.";"The syndrome of wind cold attacking the lung is commonly characterized by cinnamon twig,licorice,white peony,jujube,bupleurum,etc.";The syndrome of wind heat attacking the lung is commonly used in pinellia ternata,licorice,gypsum,ephedra,bitter almond,etc.7.Drug association analysis: The confidence level of N prescriptions was>0.8,and the support level was>0.2.45 association rules were obtained.Among them,5 representative groups were selected: Trichosanthes kirilowii-Fritillaria thunbergii,Cinnamomum cassia-White peony,Bupleurum chinense-Scutellaria baicalensis,Asarum-Dry Ginger,Vinegar Schisandra chinensis-Dry Ginger.8.Complex network analysis showed that the core prescriptions were Pinellia ternate,Poria cocos,Glycyrrhiza uralensis,Magnolia officinalis,Perilla frutescens,and Paeonia lactiflora.Conclusion:Professor Zhao Dongkai believes that in the acute stage of chronic bronchitis,the main pathological product is "phlegm retention",which is triggered by the invasion of external pathogens into the lungs and the activation of internal phlegm retention;In terms of treatment,it mainly focuses on expelling pathogenic factors,supplemented by strengthening the body,and always focuses on eliminating phlegm;The prescription is mainly based on the prescriptions of "Treatise on Febrile Diseases" and "Synopsis of the Golden Chamber",combined with the classic prescriptions of later generations,and based on the syndrome differentiation of the six meridians combined with the syndrome differentiation of the visceral channels and collaterals;The main drugs used are pinellia ternata,magnolia officinalis,and perilla frutescens,supplemented by bitter and cold baicalin,white peony,and gypsum.They are used in combination with bitterness and bitterness,and in combination with cold and warm,often accompanied by a mild and soothing insect drug called cicada molting.