| Objective:To observe the clinical effect of lotus leaf preparation in the treatment of CAG,and to evaluate the clinical efficacy and safety of lotus leaf preparation in the treatment of CAG.Methods:Sixty patients with CAG treated in the First Affiliated Hospital of Wannan Medical College from September 2020 to July 2022 were included assignedto the experimental group and control group,respectively,with 30 cases in the two groups,according to the random numbers generated by the method of random number table in advance.The experimental group was treated with lotus leaf preparation and the control group was treated with biling weitong granules.Traditional Chinese medicine symptoms,gastroscopic manifestations,histopathology,gastric functional serology,and safety indexes of patients were observed before medication and 6 months after treatment,so as to evaluate the efficacy and safety of lotus leaf preparation in the treatment of CAG.Results:1 After treatment,lotus leaf preparation group had obvious effect on improving the symptoms of epigastric fullness,noisy discomfort,fatigue and lethargy,and the total effective rate was 100.00%.2 After treatment,the lotus leaf preparation group showed significant effects in improving mucosal color,mucosal texture,intestinal metaplasia nodule and total score under gastroscopy,with a total effective rate of 93.33%.3 After treatment,Lotus leaf preparation group showed obvious effect in improving the pathological scores and total scores of the atrophy degree of the lesser curvature of gastric body,the greater curvature of gastric antrum and the lesser curvature of gastric antrum,with a total effective rate of 80.00%.In terms of improving the pathological score and the total pathological score of the greater curvature of gastric antrum and the degree of intestinal metaplasia of gastric horn,lotus leaf preparation group showed obvious effect,with the total effective rate of 69.23%.4 After treatment,the lotus leaf preparation group showed obvious effect in OLGA stage improvement,with an improvement rate of 66.67%.Lotus leaf preparation group showed obvious effect in OLGIM stage improvement,with an improvement rate of 63.33%.5 After treatment,the PGⅠ and G-17 values in the lotus leaf preparation group were significantly improved,and the positive status of G-17 in the lotus leaf preparation group was significantly improved.6 No abnormal safety indicators were detected in all subjects before medication and at the end of 6 months of treatment,and no adverse events occurred during treatment and follow-up.Conclusion:1.Lotus leaf preparation has obvious clinical effectiveness and can be used to treat patients with chronic atrophic gastritis.It can significantly improve TCM symptoms,gastroscopic manifestations,atrophy and intestinal metaplasia pathology,improve gastric function serological indexes,reduce OLGA and OLGIM grading and staging,and thusreduce the risk of gastric cancer.2.Lotus leaf preparation is safe and has no toxic side effects. |
