Clinical Study On The Effect Of Smoking On Epilepsy Severity And Cognitive Function In Male Patients

Objective(s):By evaluating the seizure frequency,seizure severity,cognitive function and quality of life of Epilepsy(EP)smoking group and non-smoking group,the influence of smoking on on the severity of epilepsy was discussed in male patients,and the characteristics and influencing factors of epilepsy cognitive dysfunction were analyzed.Methods:Male patients with epilepsy(PWE)who visited our hospital from October 2021 to January2023 were collected and divided into smoking group and non-smoking group for general data collection.Seizures were evaluated by National Hospital Seizure Severity Scale(NHS3)and seizure frequency.Montreal cognitive assessment(Mo CA),Auditory Verber Learning Test(A VLT-H),Symbol Digit transformation test(SDMT)and Trail making test(TMT)measured cognitive function in smoking group and non-smoking group.To evaluate Quality of Life Using Quality of life in Epilepsy 31(QOLIE-31).In the smoking group.Smoking status was evaluated according to the fagerstrom test of nicotine dependence(FTND)and smoking index.Collate and collect data,quantify variable data that need statistics,and conduct statistical analysis.Results:1.Compared with the non-smoking group,the score of seizure frequency and seizure severity assessment(NHS3)in the smoking group was significantly increased(P < 0.01);compared with the 0 < smoking index < 200 group,the seizure frequency in the smoking index ≥200 group was increased(P < 0.05),and the difference in NHS3 was not statistically significant(p > 0.05).2.People with epilepsy had lower scores on neuropsychological assessment,and MoCA and memory function scores were decreased compared with the cut-off value of diagnostic cognitive impairment(P < 0.05).Compared with non-smoking group,smoking group had lower scores on some neuropsychological assessment,including Mo CA,auditory word test,symbol number conversion test and connection test B.The difference was statistically significant(p < 0.05).3.Compared with the non-smoking group,the scores of seizure anxiety,cognitive function and long-term antiepileptic drug concerns in the assessment of epileptic quality of life were lower in the smoking group(P < 0.05).4.MoCA score of People with epilepsy was negatively correlated with smoking,age,seizure frequency and seizure severity;And the number of years of education is positively correlated.Conclusion(s):1.In male patients,smoking is negatively correlated with seizure frequency,seizure severity and cognitive function(including overall cognitive function,memory,information processing speed and executive function),and is dose-dependent in seizure frequency,which worsens the quality of life of epileptic patients and requires early assessment,identification and intervention.Non-smoking may improve the clinical outcome of PWE.2.Neuropsychological evaluation scores of male patients with epilepsy were all low,and the impairment of memory function was particularly obvious.3.The decrease of MoCA score in in male patients was correlated with smoking,seizure frequency,seizure severity,years of education,and age.