| Objective:To investigate the correlation between Traditional Chinese Medical(TCM)syndrome patterns and Gastrin-17(G-17)levels in Chronic Atrophic Gastritis(CAG)with intestinal metaplasia(IM),by analyzing the distribution of TCM syndrome patterns in patients with CAG with IM and the changes in serum G-17 in patients with CAG with IM and the changes in the level of G-17 in different degrees of IM,in order to provide reference for the treatment of CAG with IM in TCM using objective indicators,to achieve early diagnosis and early treatment of the disease,and to take advantage of the treatment of this disease in TCM.Methods:Collected 384 patients with CAG with IM who visited the Gastrointestinal Endoscopy Center of Fuzhou Hospital of TCM,measured the serum G-17 level,filled out a questionnaire containing general information,pathological information and information of the four diagnoses of TCM,and finally organized and analyzed the statistics.Results:1.General information:In this study,there were 384 patients with CAG with IM,and the overall distribution of IM degree:mild intestinalization(62.24%)>moderate intestinalization(30.21%)>severe intestinalization(7.55%),and the distribution of IM degree was statistically different(P<0.05).①The distribution of IM degree was as follows:mild intestinalization(63.76%)>moderate intestinalization(31.65%)>severe intestinalization(4.59%);Males accounted for 43.22%,and the distribution of IM degree was as follows:mild intestinalization(60.24%)>moderate intestinalization(28.31%)>severe intestinalization(11.45%).There was a statistical difference in the distribution of IM degree by gender(P<0.05).②Age distribution was more common in the elderly:elderly group(47.40%)>middle-aged group(35.67%)>youth group(16.93%),and their distribution was statistically different(P<0.05).The distribution of the degree of intestinalization in the youth group:mild intestinalization(70.77%)>moderate intestinalization(23.08%)>severe intestinalization(6.15%);the distribution of the degree of intestinalization in the middle-aged group:mild intestinalization(66.42%)>moderate intestinalization(26.28%)>severe intestinalization(7.30%);the distribution of the degree of intestinalization in the elderly group:mild intestinalization(56.04%)>moderate intestinalization(35.72%)>severe intestinalization(8.24%).There was no statistical difference in the distribution of IM degree among different age groups(P>0.05);③The overall Hp positivity rate was 36.72%,and the distribution of Hp positivity rate of IM degree was:moderate enterosis(47.41%)>severe enterosis(37.93%)>mild enterosis(31.38%),and the comparison between mild and severe enterosis was statistically significant(P<0.05);④Serum G-17 Levels of serum G-17 content:severe intestinalization>moderate intestinalization>mild intestinalization,and the distribution of their G-17 content was statistically significant in different IM degrees(P<0.05).②There was no statistical difference in the distribution of syndrome types and the degree of IM,in which mild and moderate enteritis were dominated by spleen and stomach damp-heat syndrome and spleen and stomach weakness syndrome.2.TCM syndrome data:the distribution of syndrome types:spleen and stomach damp-heat syndrome(25.52%)>spleen and stomach weakness syndrome(22.14%)>stomach complex blood stasis syndrome(16.67%)>liver and stomach Qi stagnation syndrome(14.06%)>liver and stomach stagnation heat syndrome(10.94%)>stomach yin deficiency syndrome(10.68%),and their distribution was statistically different(P<0.05).①spleen and stomach damp-heat syndrome was more common in young people,spleen and stomach damp-heat syndrome and spleen and stomach weakness syndrome in middle-aged people,and spleen and stomach weakness syndrome andstomach complex blood stasis syndrome in the elderly group,as follows:frequency distribution of TCM syndrome types in the young group:spleen and stomach damp-heat syndrome(41.54%)>liver and stomach stagnation heat syndrome(20.00%)>liver and stomach Qi stagnation syndrome>(16.92%)>stomach yin deficiency syndrome=stomach complex blood stasis syndrome(9.23%)>spleen and stomach weakness syndrome(3.08%),middle-aged group TCM syndrome type frequency distribution:spleen and stomach damp-heat syndrome(26.28%)>spleen and stomach weakness syndrome(21.90%)>liver and stomach Qi stagnation syndrome(19.70%)>stomach yin deficiency syndrome(13.87%)>liver and stomach stagnation heat syndrome(10.95%)>stomach complex blood stasis syndrome(7.30%),elderly group TCM syndrome type frequency distribution:spleen and stomach weakness syndrome(29.12%)>stomach complex stasis blood syndrome The frequency distribution of Chinese medical syndrome in the elderly group:spleen and stomach weakness syndrome(29.12%)>stomach complex blood stasis syndrome(26.37%)>spleen and stomach damp-heat syndrome(19.23%)>liver and stomach Qi stagnation syndrome=stomach yin deficiency syndrome(8.80%)>liver and stomach stagnation heat syndrome(7.70%),and the distribution of syndrome types in different age groups was statistically different(P<0.05);②There was no statistical difference in the distribution of syndrome types and the degree of IM(P>0.05),in which mild and moderate intestinal were dominated by spleen and stomach damp-heat syndrome and spleen and stomach weakness syndrome,severe intestinal chemistry is dominated by spleen and stomach damp-heat syndrome and stomach complex blood stasis syndrome in the stomach ligament.③There was no statistically significant difference in Hp infection among the syndrome types(P>0.05);④Serum G-17 levels:G-17 level was higher in the spleen and stomach damp-heat syndrome,lower in the stomach yin deficiency syndrome than in the other syndrome types.There were statistical differences(P<0.05)in the levels of serum G-17 content between spleen and stomach damp-heat syndrome and spleen and stomach weakness syndrome,between stomach complex blood stasis syndrome and liver and stomach Qi stagnation syndrome,between stomach yin deficiency syndrome and liver and stomach Qi stagnation syndrome,with spleen and stomach damp-heat syndrome,between spleen and stomach weakness syndrome and liver and stomach Qi stagnation syndrome,between stomach yin deficiency syndrome and liver and stomach stagnation heat syndrome,and between liver and stomach stagnation heat syndrome and spleen and stomach damp-heat syndrome.There was no statistical difference between the remaining syndrome types(P>0.05).Conclusions:1.Among 384 patients with CAG with IM in this study,mild and moderate intestinalization was the most common and severe intestinalization was the least common,women were more likely to have IM than men,the degree of intestinalization may progress with age,and infection with Hp may promote further development of the degree of intestinalization to some extent.2.The distribution of TCM syndrome is generally characterized by spleen and stomach damp-heat syndromeand and weakness syndrome,with spleen and stomach damp-heat syndromeand in young people,spleen and stomach damp-heat syndromeand and weakness syndrome in middle-aged people,and spleen and stomach weakness syndrome and stomach complex blood stasis syndrome in the elderly group,indicating that the development of CAG with IM is closely related to the physiology and pathology of the human body and has a certain change pattern,suggesting that attention should be tailored to the individual of the disease.3.The level of serum G-17 content gradually increases with the aggravation of the degree of intestinalization.The level of serum G-17 content was higher in spleen and stomach damp-heat syndrome,and the level of G-17 in stomach yin deficiency syndrome was lower than other syndrome types.Therefore,the level of serum G-17 content may have some correlation with the TCM syndrome types,and can be used as an auxiliary indicator for clinical judgment of the severity of CAG with IM to assist clinical diagnosis and treatment. |
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