Protective Effect Of 3% Diquafosol Tetrasodium On Ocular Surface Injury During Cataract Perioperative Period

Objective: To evaluate the protective effect of 3% diquafosol tetrasodium eye drops on improving ocular surface injury in patients during cataract perioperative period.Methods: In this trial,patients who underwent cataract surgery at the hospital of the research institute were randomly assigned to the following groups: 3% diquafosol tetrasodium group,0.3% sodium hyaluronate group,blank control group.During the period of 1 month after the operation,the following procedures shall be carried out each day: 3% sodium dexamethasone eye drops were given,0.3% sodium hyaluronate eye drops were given,and no drugs to improve the ocular surface were given.Tear break-up time,SchirmerⅠtest,tear moniscus height,International Standard Ocular Surface Disease Index(OSDI)questionnaire and corneal fluorescein staining was measured 1 day before cataract surgery,1 week after cataract surgery and 1 month after cataract surgery.The corneal asymmetry index(Q)and corneal regularity index(e)were measured by corneal topography(OPD-Scan Ⅲ).Visit and collect data.Evaluate the protective effect of preventive use of 3% DQS eye drops on ocular surface injury during cataract surgery perioperative period.Results: At 1 week and month of preventive medication,there were significant differences in tear break-up time,SchirmerⅠtest,and tear moniscus height between the three groups(P<0.05),and the results of DQS group were greater than those of sodium hyaluronate group than those of the blank control group.At the 1 week and 1month of preventive medication,there was a statistically significant difference in the OSDI between the three groups(P<0.05).The scores of the sodium hyaluronate group and the DQS group were lower than those of the blank control group,but there was no statistically significant difference between these two groups(P>0.05).The results of corneal fluorescein staining between the three groups were not statistically significant in 1 week of treatment(P>0.05);1 month after the treatment,there was a statistical difference in the results of corneal fluorescein staining between the three groups(P<0.05).The scores of the sodium hyaluronate group and the DQS group were lower than those of the blank control group,but there was no statistical difference between these two groups(P>0.05).There was no significant difference in the results of corneal surface asymmetry index Q and corneal surface regularity index e(P>0.05).Conclusion: Preventive use of 3% DQS eye drops in patients during cataract perioperative period can improve tear break-up time,enhance tear film stability,relieve dry eye symptoms,and improve subjective feelings of patients.In this study,3%DQS eye drops showed the significant better results of tear break-up time,Schinner I test,and tear moniscus height than 0.3% sodium hyaluronate.The treatment is effective.It can be applied to the protection of ocular surface injury in patients with cataract during perioperative period...