| Objectives:In order to observe the efficacy and security of Shuang Shen Tang comb-ined with conventional western medicine on patients with stable angina pectoris(phlegm and blood stasis)and the effects of hs-CRP and NO,and to provide a clinical basis for the treatment of stable angina pectoris(phlegm and blood stasis).Methods:A total of 64 patients were selected from December 2021 to December2022 in the outpatient clinic of the Department of Cardiovascular Medicine IV in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine who were eligible for the evidence of phlegm-and-bloodstasis interconnection in stable angina pectoris of coronary heart disease.The patients were randomly divided into 32 cases each of Shuang Shen Tang combined with conventional western medicine treatment(test group)and conventional western medicine treatment group(control group).The duration of medication was 4 weeks,and the Seattle Angina Scale before and after treatment was observed.The clinical efficacy and safety of Shuang Shen Tang were evaluated by observing the safety indexes such as SAQ,Chinese medicine syndrome score,electrocardiogram,hs-CRP,NO index and renal function,urinary routine,stool routine + occult blood before and after the treatment.SPSS25.0 was used for statistical analysis.Results:1.SAQ: Before treatment,there was no statistically significant differe-nce between the test and control groups in the scores of all 5 dimensions(P>0.05),which were comparable at baseline.When the Seattle Angina Scale scores of the two groups were compared within the group,statistically significant differences were found in all 5 dimensions in the test group(P<0.05)and in the control group(P<0.05)in the degree of limitation of physical activity,stable state of angina,frequency of angina attacks and perception of disease.After treatment,the scores of the two groups were compared between groups,and the difference scores of the test group were higher than those of the control group in four aspects: degree of limitation of physical activity,stable state of angina,frequency of angina attacks and treatment satisfaction,and the difference between groups was statistically significant(P<0.05).2.Chinese medicine evidence points: Before treatment,the s total TCM symptom scores of the two groups were compared between groups,and there were no significant differences(P>0.05),and they were comparable at baseline.When the total TCM syndrome points of the two groups were compared within groups,the differences were statistically significant(P<0.01).When the total TCM syndrome points of the two groups were compared between groups after treatment,the total TCM syndrome points of the test group were lower than those of the control group,and the difference was statistically significant(P<0.01).The total effective rate of the control group was 77.42%,and the total effective rate of the control group was 55.17%.When the total effective rate of the TCM evidence points of the two groups were compared,the difference was statistically significant(P<0.01)3.ECG efficacy: The total effective rate of ECG efficacy was 74.19% and44.83% in the test and control groups respectively,with the test group being higher than the control group and the difference between the groups being statistically significant(p<0.05).4.Inflammatory factor hs-CRP: The difference in serum hs-CRP between the test and control groups before treatment was not statistically significant(P>0.05)and was comparable at baseline.When hs-CRP levels in the test and control groups were compared within groups,the differences were statistically significant(P<0.01).After treatment,hs-CRP levels in the test and control groups were compared between groups and the differences were statistically significant(P<0.05)with hs-CRP levels in the test group being lower than those in the control group.5.Vascular endothelial function factor NO: The difference in serum NO levels between the two groups before treatment was not statistically significant(P>0.05)and was comparable at baseline.When serum NO levels in the test and control groups were compared within groups,the differences were statistically significant(P<0.01).Comparing the serum NO levels between the two groups after treatment,the NO levels in the test group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:1.Shuang Shen Tang can improve the clinical symptoms of patients with stable angina pectoris in coronary heart disease,mainly in terms of improving the degree of limitation of physical activity,increasing the stability of angina pectoris,reducing the frequency of angina attacks,and increasing the degree of disease awareness.2.Shuang Shen Tang can improve the TCM symptoms in patients with stable angina pectoris of coronary artery disease with evidence of phlegm and stagnation.3.Shuang Shen Tang can improve ST-T changes and improve myocardial ischemia in patients with stable angina pectoris of coronary artery disease.4.Shuang Shen Tang can significantly reduce serum hs-CRP and improve inflammatory response;significantly increase serum NO level,diastolic vascular smooth muscle,inhibit platelet aggregation,reduce plaque formation and anti-thrombotic,thus improving coronary artery stenosis and reducing the occurrence of cardiovascular risk events. |
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