Correlation Of Apelin-13 And NLR With Collateral Circulation And Short-Term Prognosis In Patients With Acute Ischemic Stroke

Objective: To study the correlation between serum Apelin-13,neutrophil-to-lymphocyte ratio(NLR)expression and cerebrovascular collateral circulation in patients with acute ischemic stroke(AIS)and to investigate the effects of serum Apelin-13,NLR,and cerebrovascular collateral circulation on patients’ 90-day functional prognosis.Methods: Patients who were hospitalized in the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from September 2021 to September 2022 and were clearly diagnosed with acute ischemic stroke were included and analyzed.Serum Apelin-13 levels were measured.The whole brain angiography(DSA)was completed,and the ASITN/SIR blood flow grading system was applied to grade the patients’ cerebrovascular collateral circulation,and grade 0-2 was defined as the group with poor cerebrovascular collateral circulation,and grade 3-4 was defined as the group with good cerebrovascular collateral circulation,and statistical analysis was applied to compare the baseline data and the levels of serum Apelin-13 and NLR in the two groups.According to the modified Rankin scale(m RS)score at 90-day follow-up,the patients were divided into good prognosis group(0-2)and poor prognosis group(3-6),and the differences in serum Apelin-13,NLR,and cerebrovascular collateral circulation between the two groups were compared.Results: A total of 90 patients with acute ischemic stroke were included in the study.Compared with the group with poor cerebrovascular collateral circulation,the group with good cerebrovascular collateral circulation had higher serum Apelin-13 levels,while NLR,neutrophil count,triglycerides,and body mass index(BMI)were significantly lower,with statistically significant differences(P<0.05).Further multifactorial logistic regression analysis showed that serum Apelin-13 was a protective factor for good cerebrovascular collateral circulation,whereas neutrophil count was a risk factor for good cerebrovascular collateral circulation.ROC curve analysis suggested that the sensitivity of serum Apelin-13 in predicting good collateral circulation was 80.9% and the specificity was 81.4%.The differences in good cerebrovascular collateral circulation,serum Apelin-13 level,gender,hypertension and smoking history between patients in the good prognosis group and poor prognosis group were significant(P<0.05),and multifactorial logistic regression analysis showed that good cerebrovascular collateral circulation was an independent predictor of good prognosis(P<0.05).Conclusion: 1.In patients with acute ischemic stroke,patients with good cerebrovascular collateral circulation had higher serum Apelin-13 levels,and serum Apelin-13 may serve as an independent predictor of good cerebrovascular collateral circulation,whereas NLR did not correlate with cerebrovascular collateral circulation.2.Patients in the good prognosis group had higher serum Apelin-13 levels than those in the poor prognosis group,whereas NLR did not differ significantly between the two groups,and patients with good cerebrovascular collateral circulation had a better 90-day prognosis.