Follow-up Study On Effect Of Helicobacter Pylori Eradication On Thyroid Autoantibody And Function

Objective: To understand the risk factors of Hashimoto’s thyroiditis and explore the effect of eradication of Helicobacter pylori infection on thyroid autoantibody and function,which may bring new ideas for the treatment of thyroid diseases.Methods:Among the 567 patients admitted to Xinjiang Uygur Autonomous Region People’s Hospital,286 cases of Hashimoto’s thyroiditis were set as the case group and 281 cases of non-Hashimoto thyroiditis were set as the control group,and the general condition and laboratory indicators of the two groups were compared,and the risk factors for the pathogenesis of Hashimoto’s thyroiditis were analyzed by multivariate logistic regression.There were 192 cases of Helicobacter pylori positive in patients with Hashimoto’s thyroiditis,of which45 cases were divided into Hashimoto’s thyroiditis combined with primary hypothyroidism group according to different thyroid function,65 cases of Hashimoto’s thyroiditis combined with subclinical hypothyroidism,82 cases in Hashimoto’s thyroiditis combined with normal thyroid function,and divided into treatment group 92 cases and observation group 100 cases according to the patient’s willingness to eradicate Helicobacter pylori,no treatment was given to the observation group,and anti-Helicobacter pylori treatment was given to the treatment group.Follow-up was followed for 6 months to compare changes in thyroid autoantibodies and thyroid function levels after treatment.Results:(1)Among 286 cases of Hashimoto’s thyroiditis,235 cases were female,the female prevalence rate was 82.2%,192 cases were positive for helicobacter pylori,and the infection rate was 67.13%,all of which were significantly higher than the control group.Multivariate Logistic regression analysis showed that the OR value of H.pylori infection rate in female and H.pylori infection rate was > 1,P <0.05.(2)The levels of TPOAb and Tg Ab in helicobacter pylori positive group were175.27IU/m L,204.9IU/m L,and the prevalence of thyroid nodules was 59%,which were higher than those in helicobacter pylori negative group(P < 0.05).(3)After eradication of Helicobacter pylori in Hashimoto’s thyroiditis patients,the levels of Tg Ab and TPOAb in the treatment group were decreased compared with those before treatment,but there was no significant change in the observation group.Helicobacter pylori was eradicated in Hashimoto’s thyroiditis patients complicated with primary hypothyroidism.TSH level decreased,FT3 and FT4 levels increased,and oral thyroxine dose decreased.There were no significant changes in TSH,FT3 and FT4 levels in Hashimoto’s thyroiditis patients with normal thyroid function and Hashimoto’s thyroiditis patients with subclinical hypofunction.Conclusion:(1)Sex and Helicobacter pylori infection may be risk factors for Hashimoto’s thyroiditis.(2)The levels of TPOAb and Tg Ab and the prevalence of thyroid nodules in pylori positive patients were higher than those in pylori negative patients.(3)Eradication of helicobacter pylori in Hashimoto’s thyroiditis with primary hypothyroidism is helpful to improve thyroid function and reduce the dose of oral thyroxine.