Effect Of Body Mass Index On Assisted Pregnancy Outcomes In Women With Poseidon Groups 1 And 2

Objective:To investigate the effect of body mass index（BMI）on the outcome of ART in patients with poor ovarian response（POR）under Poseidon stratified group 1 and2 after ART treatment.Methods:The clinical data of 298 patients with Poseidon groups1 and 2 who received IVF/ICSI treatment and fresh embryo transfer in the Reproductive Medicine Center of the First Affiliated Hospital of Xinjiang Medical University from December 2017 to December 2021 were retrospectively analyzed.According to different BMI values（Chinese standard）,they were divided into:underweight group（BMI<18.5kg/m²）,normal weight group（18.5≤BMI<24kg/m²）,overweight and obesity group（BMI≥24kg/m²）.The general situation,ovulation induction and final pregnancy outcome were compared among the groups.According to Poseidon’s classification,the population was divided into PG1 group（age<35 years）and PG2 group（age≥35 years）,and the pregnancy outcomes were compared between the two groups under different BMI groups.To analyze the relationship between BMI and pregnancy outcome in patients with Poseidon groups 1 and 2.Results:The b LH was lower in overweight and obesity group（P<0.05）;The dose and days of Gn in overweight and obesity groups were higher than those in the normal and underweight groups（P<0.05）,and the levels of E₂and P on the day of HCG were significantly lower than those in other two groups（P<0.05）.There were differences in the live birth rates among BMI groups in patients with Poseidon groups 1 and 2,and the live birth rate of overweight and obesity groups were significantly lower than the normal group（P<0.05）.The live birth rate of overweight and obesity patients in the PG2 group was significantly lower than that of the normal group（P<0.05）.BMI and the good quality embryo rates were different in the live birth outcome of patients in Poseidon groups 1 and 2,and BMI was an independent risk factor for live birth in these patients.Conclusion:Overweight and obesity can result in the prolonged Gn stimulation,the increased dose of Gn,and a decrease in the live birth rate during IVF treatment for patients with unexpected poor ovarian response.Abnormal increase of BMI may adversely affect the outcome of IVF treatment in patients with unexpected poor ovarian response.