Analysis Of Clinical Characteristics And Insulin Resistance Related Risk Factors Of Newly Diagnosed Early Onset Type 2 Diabetes

Objective Due to the change of lifestyle and diet structure,the onset age of type 2diabetes presents a younger trend.More and more people are diagnosed with type 2 diabetes when they are young,which is called early onset type 2 diabetes.Compared with other types of diabetes,early onset type 2 diabetes has its unique disease characteristics.This article will discuss the clinical metabolic characteristics and chronic complications of newly diagnosed early onset type 2 diabetes,and analyze the independent risk factors related to insulin resistance.Methods 309 newly diagnosed type 2 diabetes patients(214 males and 95 females) admitted to our hospital from January 2020 to December 2021 were selected as research objects.According to the diagnosis age of patients,they were divided into two groups.Patients with diagnosis age<40 years old were classified as early-onset type 2 diabetes(referred to as early-onset group),with 85 cases in total,including 70 males and 15 females;The patients with diagnosis age≥40 years old were late onset type 2 diabetes(referred to as late onset group).There were 224 cases in total,including 144 males and80 females.Collect relevant data,including basic information of patients,biochemical indicators and clinical complications,and analyze relevant independent risk factors of insulin resistance.Results 1.Compared with the late onset group,the early onset group had higher FPG,BMI,TG,FINS,HOME-IR and other indicators,and lower HDL than the late onset group,all of which were statistically significant(P<0.05);Blood pressure,Hb A1 c,LDL,FC-P,HOME-β of patients in both groups The difference between them was not statistically significant(P>0.05).2.Compared with patients in the late onset group,patients in the early onset group had lower DPN and CAS incidence rate,and the difference was statistically significant(P<0.05).There was no statistically significant difference in DR between the two groups(P>0.05).3.With insulin resistance as the dependent variable and each index as the independent variable,a single factor logistic regression was conducted.The results showed that age,BMI,Hb A1 c,FC-P,TG and LDL increased the risk of insulin resistance in early-onset type 2 diabetes(P<0.05);The independent variables and clinically significant indicators screened above were used as independent risk factors for insulin resistance in multivariate logistic regression analysis.The results showed that the younger diagnosis age(OR=0.837),higher BMI value(OR=2.169)and higher FC-P(OR=3.824)were independent risk factors for insulin resistance(P<0.05).4.The ROC curve was used to explore the value of age,BMI and FC-P in predicting insulin resistance in newly diagnosed early onset type 2 diabetes.The results showed that the area under the ROC curve for predicting insulin resistance by age was 0.752,P<0.000;The area under the ROC curve of BMI predicting insulin resistance was 0.915,P<0.000;The area under the ROC curve predicted by FC-P is 0.752,P<0.05.Conclusion 1.FPG,BMI,TG,FINS,HOME-IR and other indicators of newly diagnosed early onset type 2 diabetes were higher,HDL was lower than that of late onset group,glucose and fat metabolism was more disordered,and the incidence of insulin resistance was higher.2.Among the chronic complications of diabetes,the incidence of diabetes peripheral neuropathy and carotid atherosclerosis in the early onset group was lower than that in the late onset group,and the incidence of diabetes retinopathy was not significantly different between the two groups.3.Age,BMI and FC-P are independent risk factors for insulin resistance in newly diagnosed early onset type 2 diabetes.