The Predictive Value Of PLR,NLR For Detecting Anastomotic Leakage After Esophageal Resection

Objective:Objective to investigate the inflammation-related indicators after radical resection of esophageal cancer,such as Neutrophil to lymphocyte ratio(NLR),Platelet to lymphocyte ratio(NLR),The predictive value of postoperative Anastomotic leakage(AL)of PLR.Methods:This is a retrospective analysis.Patients who underwent Mc Keown operation in the cardiothoracic Surgery Department of the Affiliated Hospital of Youjiang Medical College for Minorities from January 2020 to December 2022 for esophageal malignancies were included.According to the inclusion criteria,patients who received neoadjuvant chemotherapy before surgery and those who were complicated with other malignant tumors or had distant metastasis before surgery were excluded.Postoperative anastomotic fistula was detected in the experimental group,and no Postoperative anastomotic fistula occurred in the control group.Postoperative data were categorized in Postoperative days(POD 1)and Postoperative days(POD 1,postoperative days).NLR and PLR data in POD 2),POD 3 days after surgery,and single factor analysis were performed on preoperative albumin,operation time,tumor site,Body Mass Index(BMI),etc.Receiver operating characteristic curve(ROC curve)and multivariate logistic analysis were carried out.To evaluate the correlation between NLR,PLR and anastomotic fistula after esophageal cancer surgery.Results:By analyzing the medical records of the two groups,there were no significant differences in gender,age,BMI,diabetes,hypertension,smoking history,preoperative albumin,tumor site,operation time,postoperative blood loss,NLR POD2 and PLR POD2(p > 0.05).Previous drinking history,NLR POD1,NLR POD3,PLR POD1,PLR POD3 were significantly different(p < 0.05).The characteristic indicators of the five groups were found by Lasso regression as above,and the specific indicators of the five groups were incorporated into the binary logistic analysis,which showed no statistical significance in drinking history(P > 0.05).The ROC curve analysis showed that the Area under curve of NLR POD1,AUC)area was0.739,and the optimal truncation value was 9.508.The AUC area of NLR POD3 is0.641,and the best truncation value is 21.577.The AUC area of PLR POD1 was0.695,and the best truncation value was 240.782.The AUC area of PLR POD3 is0.698 and the best truncation value is 0.022.Conclusion:PLR POD1,PLR POD3,NLR POD1 and NLR POD3 have a certain value in predicting the occurrence of postoperative anastomotic fistula,while PLR POD2 and NLR POD2 have no significant value in predicting the occurrence of postoperative anastomotic fistula.