Analysis Of Clinicopathologic Features In 581 Patients From A Third Class A Hospital And Risk Factors Analysis Of Concurrent Peritoneal Metastasis Of Colon Cancer

Objective:(1)To analyze the clinicopathologic features and molecular typing of colon cancer and rectal cancer,in order to provide evidence for treating colon cancer and rectal cancer as different clinicopathologic entities according to their anatomical location;(2)To explore the risk factors for the occurrence of synchronous peritoneal metastasis in patients with colon cancer,so as to improve the early diagnosis rate of synchronous peritoneal metastasis of colon cancer and enable patients to receive timely treatment.Methods:(1)Patients with first diagnosis of colon cancer admitted to the Affiliated Hospital of Yan ’an University during the 10 years from January 1,2013 to December 31,2022 and patients with first diagnosis of rectal cancer admitted to the Affiliated Hospital of Yan ’an University during the 3 years from January 1,2020 to December 31,2022 were selected as the study subjects;(2)All patients were pathologically diagnosed with colorectal cancer.The basic information,clinicopathology,laboratory indicators,molecular typing and other data of all patients were collected;(3)Univariate analysis was performed to compare the differences in clinicopathologic features,laboratory indicators,and molecular typing between colorectal cancer and colon cancer groups with and without concurrent peritoneal metastasis.The statistically significant indicators obtained by univariate analysis and the factors associated with synchronous peritoneal metastasis of colon cancer were incorporated into binary Logistic regression analysis to obtain the independent risk factors for synchronous peritoneal metastasis of colon cancer.Results:(1)There were more differences in clinical manifestations,pathological types and degrees of differentiation,maximum tumor diameter,complications(intestinal obstruction,intestinal perforation,bleeding)and distant metastatic sites of colorectal cancer(P < 0.05);(2)Pathological type is an independent risk factor for synchronous peritoneal metastasis of colon cancer.Conclusions:(1)Colon cancer and rectal cancer in this group have different clinicopathological features and biological behavior.These differences indicate that colorectal cancer is necessary to be divided into two diseases,namely colon cancer and rectal cancer;(2)Patients with elevated CA19-9,right colon cancer,mucinous adenocarcinoma/partial mucinous adenocarcinoma,T4,N2 were more likely to develop peritoneal metastasis.