Risk Factors For Low Anterior Resection Syndrome Of Rectal Cancer

Objective:To investigate the risk factors of low anterior resection syndrome in patients with rectal cancer.Methods:Retrospectively analyzed the clinical data of patients who underwent low anterior resection from January 2018 to May 2021 in the Department of General Surgery,Zhongda Hospital,Southeast University.The patientswere divided into two groups: the group without LARS and the group with LARS according to the LARS scale.The relationship between the LARS and research indicators of patientswere compared in four periods: 1-3 months、4-6 months、7-18 months and 19 months after surgery.Results:76 cases were included in this study.The analysis shows that:1.The incidence of LARS in patients with rectal cancer after low anterior resection ranged from 69.7% to 39.1%.With the progress of time,LARS was self-limited in some cases,but still some cases continued to have problems with defecation function after surgery.2.The distance between the tumor and the anal margin was an independent risk factor of LARS.With the progress of time,compared with the high rectal tumor group,the risk of LARS in the low rectal tumor group gradually increased from 8.46 times in the 1-3 months to19.81 times in the 19 months after surgery.3.In 1-3 months,both age and BMI were risk factors of LARS.Age was an independent factor of LARS.Compared with patients aged ≥65years,patients aged < 65 years had a 4.007 fold higher risk.(95% C.I.1.217 ～ 13.196,P< 0.05).However,the effect of both age and BMI on the incidence of LARS was not statistically significant in other periods.4.In 4-18 months,tumor diameter is a risk factor of LARS.5.In the period of 19 months after surgery,gender,ischial internodule diameter,ischial interspinous diameter and tumor diameter were risk factors of LARS.Gender was an independent factor in the period of Eighteen months.The risk of LARS in the period of 19 months after surgery was 5.385 times higher in women than in men(95% C.I.1.600 ～ 18.129,P< 0.05).Conclusion:The distance between the tumor and the anal margin was an independent risk factor of LARS at each postoperative time.In1-3 months,both age and BMI were the risk factors of LARS.In 4-18 months,tumor diameter was a risk factor of LARS.In the period of 19 months after surgery,gender,ischial internodule diameter,ischial interspinous diameter and tumor diameter were risk factors of LARS.