Prediction Effect Of ICG-R15 On Liver Function Injury After Different Treatment Methods In Patients With Hepatocellular Carcinoma

Purpose : Hepatocellular carcinoma(HCC)is a common malignant tumor.Hepatectomy,transarterial chemoembolization and hepatic arterial infusion chemotherapy are the main methods for treatment,and the evaluation of liver function reserve before treatment is an important index for patients to choose methods for treatment and predict prognosis.Among them,ICG-R15,ChildPugh score and ALBI score have been widely used in previous studies,and each has its own advantages and disadvantages in evaluating liver function.The purpose of this study was to compare the prediction of liver function injury in patients with hepatocellular carcinoma after hepatectomy,transarterial chemoembolization and hepatic arterial infusion chemotherapy by ICG clearance test,Child-Pugh score and ALBI score.Methods:Clinical data of 121 inpatients with hepatocellular carcinoma in the Department of Hepatobiliary Surgery of Hospital from January 2019 to July 2021 were collected to study the predictive value of the liver function related indicators and liver function reserve assessment methods retrospectively.The liver function injury after treatment was analyzed by binary Logistic regression.The cut-off values of ICG-R15,Child-Pugh score and ALBI score were determined by Receiver Operating characteristic(ROC)curve.The prediction efficiency of the three methods was compared by Area under the curve(AUC).The correlation between the three assessment methods was determined by Pearson correlation analysis.Results:In predicting liver failure after hepatectomy,ICG-R15 had the highest Area under the curve(AUC=0.832),with 87.5% sensitivity and 85.4% specificity,which were higher than the Child-Pugh score(AUC=0.633)and the ALBI score(AUC=0.732).The cut-off value was18.9%.ICG-R15 was an independent risk factor of post-hepatectomy liver failure.In the treatment of HAIC,the AUC of ICG-R15,Child-Pugh score and ALBI score were 0.729,0.721 and 0.719,respectively,and there were no significant difference among them.ICG-R15 was positively correlated with Child-Pugh score and ALBI score.Concusions:ICG-R15 was superior to Child-Pugh score and ALBI score in predicting posthepatectomy liver failure,and also an independent risk factor of post-hepatectomy liver failure.The ability of the three methods of liver function reserve to predict severe liver injury after TACE and HAIC treatment in HCC patients was basically consistent.