A Study On The Effect Of High-flow Humidified Oxygen Therapy In Weaning From Mechanical Ventilation

Objectives To observe the effects of high-flow humidified oxygen therapy on respiration and circulation of patients with severe nerve invasive mechanical ventilation,and to evaluate the effect of high flow humidified oxygen therapy on mechanical ventilation evacuation of severe nerve invasive mechanical ventilation patients.Methods Severe nerve invasive mechanical ventilation patients in Tangshan Gong Ren Hospital from January 2020 to December 2021 were randomly divided into the experiment group and the control group,the experiment group used high-flow humidified oxygen therapy and the control group used heal and moisture exchanger therapy.The vital signs of patients in the two groups monitored.RR（respiratory rate）,Pa CO₂（pressure of carbon dioxide）,Pa O₂（pressure of oxygen）,P/F（oxygenation index）,HR（heart rate）,SBP（systolic blood pressure）,DBP（diastolic blood pressure）,MAP（mean arterial pressure）and viscosity of sputum were recorded at 0,6,12,24,48 hours after weaning from mechanical ventilation.The changes of RR,Pa CO₂,Pa O₂,HR,SBP,DBP,MAP were calculated,the success rates of the two groups on weaning from ventilation evacuation were analyzed.Results 1 There were statistically significant differences in respiration rate after weaning from ventilation evacuation 24h（t=-2.240,P=0.029）and the changes of respiration rate after weaning from ventilation evacuation 24h（t=-2.417,P=0.019）with two groups.2There were statistically significant differences in systolic blood pressure after weaning from ventilation evacuation 24h（t=2.225,P=0.030）and the changes of systolic blood pressure after weaning from ventilation evacuation 24h（t=2.958,P=0.004）with two groups.3 There were statistically significant differences in the changes of mean arterial pressure after weaning from ventilation evacuation 24h with two groups（t=3.133,P=0.003）.4 There were statistically significant differences in the changes of diastolic blood pressure after weaning from ventilation evacuation 24h with two groups（t=2.068,P=0.043）.5 There were statistically significant differences in viscosity of sputum after weaning from ventilation evacuation 6 hours（x²=4.838,P=0.028）,12 hours（x²=4.436,P=0.035）,24 hours（x²=5.424,P=0.020）,48 hours（x²=8.222,P=0.004）with two groups.6The success rate of weaning from ventilation evacuation in the experiment group（87.5%）was higher than that the control group（64.3%）and the difference was statistically significant（x²=4.499,P=0.034）.7 There were no significant differences in other indicators（P>0.05）.Conclusions 1 High-flow humidified oxygen therapy can improve patients’respiratory and circulatory function by reducing breathing rate and raising blood pressure.2 High-flow humidified oxygen therapy can reduce viscosity of sputum.3 High-flow humidified oxygen therapy improve the success rate of mechanical ventilation evacuation in patients with severe nerve with invasive mechanical ventilation in sequential treatment of mechanical ventilation evacuation.Figure 3;Table19;Reference 152...